When: March 30, 2016, 2:00 PM
Location: 3rd Floor Orchard View Room , Discovery Building
Contact: 608-316-4401, firstname.lastname@example.org
Deciphering the effects of gut microbes, host genetics, and diet on metabolic disease
The collections of microbes (i.e., microbiota/microbiome) that inhabit the human intestine have profound effects on our development, physiology and health. Alterations in the gut microbiota contribute to metabolic disorders including obesity, type-1 and type-2 diabetes, and cardiovascular disease. Diet and host genetics are key factors controlling the assembly and dynamic operations of the gut microbiota. However, a major remaining challenge is to understand how genes and diet interact to select for beneficial vs. disease-causing microbiota. Our research aims to dissect the interactions between gut microbes, host genetics, and diet, and to test their impact on the development of metabolic phenotypes. Specifically, we’ve focused on two mouse strains that develop disparate metabolic phenotypes in response to chronic high-fat high-sucrose feeding (HF/HS): C57BL/6J mice become obese, insulin resistant and hyperglycemic, whereas CAST/Ei mice remain lean and sensitive to insulin despite the dietary challenge. We used a combination of gnotobiotics, metabolomics, and next-generation sequencing to show that gut bacterial families correlate with diabetes-related phenotypes and the metabolic responsive to HF/HS diet can be altered via gut microbes.
All QBio sponsored talks take place on Wednesdays at 2:00 p.m. in the 3rd floor Orchard View room of the Discovery Building. Talks are open to the public. Access to the room is via the elevator behind Aldo’s Cafe in the Northeast corner of the building.