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SysBioM Seminar – John Pool

Event Details

When: February 11, 2015, 1:00 PM

Location: 1st floor (west end of building by the Entrepreneurial Resource Center), Discovery Building

Cost: Free and open to the public

Contact: 608-316-4325, plpointer@wisc.edu

John Pool

John Pool

John Pool talks about The Genomic Consequences of Population Admixture in Drosophila:  a Network of Fitness Interactions

North American populations of Drosophila melanogaster are thought to derive from both European and African source populations, but despite
their importance for genetic research, patterns of admixture along their genomes are essentially undocumented.  Here, I infer geographic ancestry along genomes of the Drosophila Genetic Reference Panel (DGRP) and the D. melanogaster reference genome.  Overall, the proportion of African ancestry was estimated to be 20% for the DGRP and 9% for the reference genome.  Based on the size of admixture tracts and the approximate timing of admixture, I estimate that the DGRP population underwent roughly 13.9 generations per year.  Notably, ancestry levels varied strikingly among genomic regions, with significantly less African introgression on the X chromosome, in regions of high recombination, and
at genes involved in specific processes such as circadian rhythm.  An important role for natural selection during the admixture process was further supported by a genome-wide signal of ancestry disequilibrium, in that many between-chromosome pairs of loci showed a deficiency of Africa-Europe allele combinations.  These results support the hypothesis that admixture between partially genetically isolated Drosophila populations led to natural selection against incompatible genetic variants, and that this process is ongoing.  The ancestry blocks inferred here are relevant for the performance of reference alignment in this species, and may bolster the design and interpretation of many population genetic and association mapping studies.

Discovery Bldg ERC map

SysBioM Seminars are sponsored by the Systems Biology Theme in the Wisconsin Institute for Discovery and feature speakers from various disciplines of Systems Biology including, but not limited to Genetics, Biostatistics, Microbiology, and Chemical and Biological Engineering.

The talks are located on the first floor west side of the Discovery Building in the ERC Lobby.

For more information please contact plpointer “at” wisc.edu