Postdoc, Systems Biology
- B.A., Physics, Lawrence University
- B.S., Mechanical Engineering, Washington University in St. Louis
- Ph.D., Biomedical Engineering, University of Wisconsin–Madison
During a virus infection, the various processes and interactions of the virus, host, and environment form a complex and dynamic system with a heterogeneous range of cell states and outcomes. Even under the controlled conditions of in vitro culture, infections initiate and progress at different times and rates amidst a variety of host responses. Such broad diversity can make the study of infections difficult, but it also offers an opportunity to learn more about the system as a whole. By observing and quantifying individual cell behavior using microscale devices and computational tools, I hope to better understand the factors that contribute to such heterogeneity, and thereby learn more about the salient parameters of the underlying biology. I have had the opportunity to begin developing these strategies using vesicular stomatitis virus, a well-studied negative-sense, single-stranded RNA virus that provides an excellent system for studying genetic rearrangements and evolution. As the methods become more mature, we hope to apply them to human rhino-virus infections and other complex, dynamic, and heterogenous processes that affect human health.