Deciphering Gene Regulatory Networks
Systems Biology researcher Sushmita Roy is leading an effort putting computational methods to work characterizing the gene regulatory networks responsible for cell differentiation.
Featured Science
Stories about discoveries, advancements, and forward-thinking ideas from WID’s research areas, hubs, and key collaborators.
Gut’s Microbial Community Shown to Influence Host Gene Expression
The upshot of the study from researchers in the Epigenetics theme at WID is another indictment of the so-called Western diet, high in saturated fats, sugar, and red meat.
Aging Leaves: How Epigenetic Regulation Gives Rise to the Signature Colors of Fall
Xuehua Zhong describes an epigenetic mechanism behind plant aging for the first time in a ground-breaking new paper in eLife.
Can Artery ‘Banks’ Transform Vascular Medicine?
BIONATES Lih-Sheng “Tom” Turng works in tandem with Morgridge Institute for Research scientist James Thomson to create scaffolds for small diameter arteries.
Smart Cancer Therapies: Teaching the Body’s Own T-cells to Attack Tumors
Kris Saha with colleagues David Beebe and Christian Capitini aim to develop improved methods for making CAR T-Cells with a two-year grant from the NSF.
Learning Like Humans, Machines Extend the Reach of Research
WID Optimization researchers have partnered with faculty across campus to work on ways to use computers to make better use of human brain power.
Understanding the Immune System with Machine Learning
Systems Biology researchers Deborah Chasman and Sushmita Roy are using machine learning to identify virus and pathogenicity-specific regulatory networks which may guide the design of effective therapeutics for infectious diseases. The work is described in a recent paper in PLOS Computational Biology.
Epigenetics Researcher Named Pew Scholar in Biomedical Sciences
WID Principal Investigator Peter Lewis honored for work on modifying histones to treat cancer.
Gene Regulatory Mutation Linked to Rare Childhood Cancer
Epigenetics researcher Peter Lewis has linked a histone mutation to a rare pediatric bone cancer, an important step in understanding and treating more common cancers.
Inhibitory Interactions Promote Frequent Bistability Among Competing Bacteria
Systems Biology researchers explore the importance of community history and assembly when considering microbial communities in a paper in Nature Communications.
Mass Spectrometry Brings Epigenetics into Focus at UW
The Epigenetics theme at WID is putting mass spectrometry to use in new ways with specialized workflows designed to uncover the mysteries of chromatin.
Finding Meaning in Big Data
Discovery fellows Rebecca Willett and Rob Nowak are creating algorithms to make sense of big data and help machines learn.
NEOS Optimizes Itself: New Solvers and Authentication Services Added
Within the past year NEOS has made its services more resilient, sophisticated and diverse.
Siftr: Web tool for citizen science, ethnography, teaching
Siftr from the Field Day Lab creates a clearinghouse for the creation of citizen science projects.
The Strategic Value of Carbon Tariffs
Professor Thomas Rutherford, WID Optimization, and colleagues used numerical models to examine whether the threat of carbon tariffs might lower the cost of reductions in world carbon emissions in a paper published in the February issue of the American Economic Journal: Economic Policy.
Professor Lih-Sheng (Tom) Turng: Advancing Microcellular Polymers
Thanks to the research of Professor Lih-Sheng (Tom) Turng, plastics can have applications in products ranging from eyeglass lenses to engineered tissues.
LEL and CAVE Featured on Big Ten Network Video Profile
Patti Brennan and Kevin Ponto illuminate the CAVE for a B1G television audience.
Educational Innovation: ISyE junior design course uses blended learning and lego kits to teach fundamental skills of design
Discovery Fellow Rob Radwin uses blended learning and LEGO kits to solve real world problems.
Epigenetics Research at UW-Madison Ready for the Next Step
John Denu, Epigenetics Theme leader, keeps UW-Madison on top of research in epigenetics.
High-Content Analysis of CRISPR-Cas9 Gene-Edited Human Embryonic Stem Cells
Kris Saha and colleagues from the BIONATES Theme detail a new approach that can refine gene editing in this month’s issue of Stem Cell Reports.
Systems Biology Researchers Study Co-infections of Viable and Defective Viruses
The paper, titled ‘High-throughput single-cell kinetics of virus infections in the presence of defective interfering particles’, was published in the current issue of the Journal of Virology.
Imagining a Healthier Future
Patricia Flatley Brennan seeks to utilize imagination to optimize patient healthcare outcomes.
The Science of Funny: Active Machine Learning & Cartoons
The New Yorker is using a machine learning system developed by WID Optimization researchers to sort through captions for their weekly cartoon caption contest.
Origins of Life… and John Yin
John Yin, Professor of Chemical Engineering and Systems Biology theme leader at WID, is beginning an interdisciplinary initiative to examine the origins of life with new methods, approaches, and perspectives.
DECIPHER: harnessing local sequence context to improve protein multiple sequence alignment
Researchers at WID are continually publishing premier research in top publications. Here, we feature some of the most important and transformative scientific publications from our community.