When: April 19, 2017, 2:00 PM
Location: 3rd Floor Orchard View Room , Discovery Building
Contact: 608-316-4401, email@example.com
Understanding transcriptional regulation in bacteria on a genomic scale
Understanding bacterial transcriptional regulation on a genomic scale, which is essential to achieve the broad goals of manipulating bacteria for synthetic biology and controlling the properties of microbiomes, faces a fundamental dilemma. Genome-scale methods like ChIP-seq or RNA-seq typically yield aggregated pictures of gene regulation, but the mechanisms that regulate individual genes are specialized, diverse, and highly evolved for the particular functions of each gene. Further, nucleoid-structuring proteins, which govern gene expression on a global scale, form irregular and heterogeneous structures. I will describe our efforts to dissect genome-scale regulation of transcription focused on the roles of elongation factors, transcription-translation coupling, and nucleoid-structuring proteins. I will discuss the complications caused by the highly evolved and specialized nature of bacterial gene regulation using examples.
All qBio sponsored talks take place on Wednesdays at 2:00 p.m. in the 3rd floor Orchard View room of the Discovery Building unless otherwise noted. Talks are open to the public. Access to the room is via the elevator behind Aldo’s Cafe in the Northeast corner of the building.