When: April 27, 2016, 2:00 PM
Location: 3rd Floor Orchard View Room , Discovery Building
Contact: 608-316-4401, firstname.lastname@example.org
The genetics of preclinical risk factors for Alzheimer’s disease
Although a family history of Alzheimer’s disease (AD) is the strongest predictor of late onset AD, genetic variants to date account for a relatively small amount of the heritability of this disease. It is likely that complex relationships between genetic variants and environmental factors contribute to the onset of AD; however, these relationships have typically been extremely difficult to identify. Using the Wisconsin Registry for Alzheimer’s Prevention (WRAP), a cohort study enrolling initially asymptomatic participants enriched with a parental history of AD, we are exploring two methods that utilize resulting decision trees from Random Forest, a machine learning method, to explore the potential for gene-environment interactions influencing risk factors for AD. We are also exploring the use of metabolomics as environmental measures to further investigate gene-environment interactions. Using pilot data from WRAP, we conducted a metabolome-wide association study (MWAS) comparing metabolomic profiles of a subset of participants showing cognitive decline to age- and sex-matched cognitively stable participants. Preliminary results suggest that amino acids may be relevant to early changes in cognition.
All QBio sponsored talks take place on Wednesdays at 2:00 p.m. in the 3rd floor Orchard View room of the Discovery Building. Talks are open to the public. Access to the room is via the elevator behind Aldo’s Cafe in the Northeast corner of the building.