When: April 29, 2015, 1:00 PM
Location: 1st floor (west end of building by the Entrepreneurs' Resource Clinic), Discovery Building
Cost: Free and open to the public
Contact: 608-316-4325, firstname.lastname@example.org
Modeling Host Responses to Understand Severe Human Virus Infections
Infection of an organism by a pathogen triggers a complex host response that is necessary to protect the infected organism, but which also can contribute to lethal disease. How the host response is triggered and controlled and the mechanisms that determine the outcome of infection are not well understood. The OMICS-LHV (Lethal Human Viruses) project is a multidisciplinary, multi-institutional collaborative project that aims to develop a comprehensive understanding of the host response to unique viruses that cause lethal infections in humans – influenza A viruses, Ebola virus, Middle Eastern Respiratory Syndrome coronavirus (MERS-CoV), and West Nile virus (WNV) – using a systems biology approach. Our approach comprises making global measurements of host molecule changes in different cells or tissues infected with these viruses; using computational analyses and modeling to make predictions about what controls these changes; and testing these predictions to refine the models. The knowledge gained from this work is expected to provide a foundation for better understanding the host response to lethal human virus pathogens, and to facilitate the development of improved strategies for intervening with lethal virus diseases. In this talk, I will give an overview of the OMICS-LHV research program and provide vignettes of some of our ongoing research projects.
SysBioM Seminars are sponsored by the Systems Biology Theme in the Wisconsin Institute for Discovery and feature speakers from various disciplines of Systems Biology including, but not limited to Genetics, Biostatistics, Microbiology, and Chemical and Biological Engineering.
The talks are located on the first floor west side of the Discovery Building in the ERC Lobby.
For more information please contact plpointer “at” wisc.edu