When: April 15, 2015, 1:00 PM
Location: 1st floor (west end of building by the Entrepreneurial Resource Center), Discovery Building
Cost: Free and open to the public
Contact: 608-316-4325, firstname.lastname@example.org
Elucidating the Role of Biophysical Cues in Human Somatic Cell Reprogramming
Cellular reprogramming has the potential to revolutionize the biomedical field as a patient-specific cell source for disease modeling and regenerative medicine. However, the mechanisms by which reprogramming cells integrate physical and chemical signals to progress through epigenetic transitions are not well understood. As a result, reprogramming processes are notoriously noisy and inefficient. We will describe experiments – exploiting high-content imaging of the cytoskeleton, nucleus and chromatin – that seek to efficiently accelerate epigenetic transitions. Ultimately, we aim to identify biophysical changes accompanying reprogramming processes, assess how these changes alter the epigenetic status of reprogramming cells, and perturb biophysical inputs to both understand and engineer epigenetic transitions.
SysBioM Seminars are sponsored by the Systems Biology Theme in the Wisconsin Institute for Discovery and feature speakers from various disciplines of Systems Biology including, but not limited to Genetics, Biostatistics, Microbiology, and Chemical and Biological Engineering.
The talks are located on the first floor west side of the Discovery Building in the ERC Lobby.
For more information please contact plpointer “at” wisc.edu