Brittany Albaugh

Brittany Albaugh
Graduate Student, Epigenetics

Years at WID

2011 - present2015

Education

  • B.S., Cell and Molecular Biology, Grand Valley State University
  • Ph.D., Biochemistry, University of Wisconsin–Madison

Research Description

Brittany Albaugh studied the mechanism of acetylation by the yeast HAT Rtt109. Rtt109 is a novel histone acetyltransferase that requires a histone chaperone, either Asf1 or Vps75, for efficient activity. Rtt109 can acetylate lysine 56 on histone H3 as well as tail residues K9, K14, K23 and K27. Lysine 56 acetylation has been shown to be required for histone deposition onto chromatin during replication and histone turnover during the DNA repair response.

Albaugh worked to understand the mechanisms of acetylation by Rtt109. Rtt109 has distinct activities whether in complex with Asf1 or Vps75 and how this occurs was a focus of her research. Additionally, she worked on the catalytic mechanism of Rtt109-Vps75 complex and how Rtt109 activities are regulated by autoacetylation.

Honors

  • 2011: Biochemistry Department Graduate Student Teaching Award.
  • 2010: Poster competition winner of Chromatin and Transcription symposia in the ASBMB National Conference.
  • 2010: Recipient of ASBMB National Conference Graduate Student Travel Award
  • 2009, 2010: Recipient of Vilas Travel Award
  • 2009: Recipient of FASEB summer conference poster travel award
  • 2009: Bimolecular chemistry travel award
  • 2006: Recipient of ASBMB National Conference Undergraduate Student Travel Award
  • 2004–06: Phi Kappa Phi Academic Honor Society

Selected Publications

  • Kolonko, E. M., Albaugh, B. N., Lindner, S. E., Chen, Y., Satyshur, K. A., Arnold, K. M., Kaufman, P. D., Keck, J. L., and Denu, J. M. (2010) Proc Natl Acad Sci USA 107, 20275-20280
  • Albaugh, B. N., Arnold, K. M., and Denu, J. M. (2011) Chembiochem 12, 290-298
  • Albaugh, B. N., Kolonko, E. M., and Denu, J. M. (2010) Kinetic mechanism of histone acetyltransferase and chaperone complex, Rtt109-Vps75, Biochemistry.
  • Albaugh, B. N., Hallows, W. C., and Denu, J. M. (2008) Where in the cell is SIRT3?–functional localization of an NAD+-dependent protein deacetylase, Biochem J 411, e11-13.
  • Berndsen, C. E., Albaugh, B. N., Tan, S., and Denu, J. M. (2007) Catalytic mechanism of a MYST family histone acetyltransferase, Biochemistry 46, 623-629.
  • Wallar, B. J., Stropich, B. N., Schoenherr, J. A., Holman, H. A., Kitchen, S. M., and Alberts, A. S. (2006) The basic region of the diaphanous-autoregulatory domain (DAD) is required for autoregulatory interactions with the diaphanous-related formin inhibitory domain, J Biol Chem 281, 4300-4307
  • 2010: Poster presentation at National ASBMB meeting: Kinetic mechanism of a novel HAT-histone chaperone complex, Rtt109-Vps75
  • 2006: Poster presentation at National ASBMB Meeting: Probing the specific amino acid residues involved in the regulation of the Diaphanous-related Formins