Coral Wille

Coral Wille
330 North Orchard Street
Madison WI 53715
Room 2135D-1
ckwille@wisc.edu

Epigenetic barriers of reprogramming somatic cells to induced pluripotent stem cells

Years at WID

2015 - present

Education

  • B.S., Cellular and Molecular Biology, and Genetics, University of Delaware–Newark
  • Ph.D., Microbiology, University of Wisconsin–Madison

Research Description

Coral Wille is exploring how the DOT1 H3K79 methyltransferase interacting factors, AF9 and AF10, affect reprogramming efficiency of induced pluripotent stem (iPS) cells.

Affiliations

American Society of Microbiology

Honors

  • Virology Training Grant (2010-2012)
  • Shapiro Scholarship (2009)
  • Phi Beta Kappa (2009)
  • HHMI Research Scholar (2007)

Selected Publications

  • Wille CK, Nawandar DM, Henning AN, Ma S, Oetting KM, Lee D, Lambert PF, Johannsen EC, and Kenney SC. 2015. 5-hydroxymethylation of the EBV genome regulates the latent to lytic switch. Proc. Natl. Acad. Sci. U.S.A. [Epub ahead of print].
  • Nawandar DM, Wang A, Makielski K, Lee D, Ma S, Barlow E, Reusch J, Jiang R, Wille CK, Greenspan D, Greenspan JS, Mertz JE, Hutt-Fletcher L, Johannsen EC, Lambert PF, and Kenney SC. 2015. Differentiation-dependent KLF4 expression promotes lytic Epstein-Barr Virus infection in epithelial cells. PLoS Pathog. 11:e1005195.
  • Wille CK, Nawandar DM, Panfil AR, Ko MM, Hagemeier SR, and Kenney SC. 2013. Viral genome methylation differentially affects the ability of BZLF1 versus BRLF1 to activate Epstein-Barr virus lytic gene expression and viral replication. J. Virol. 87:935-950.
  • Hoebe EK, Wille C, Hopmans ES, Robinson AR, Middeldorp JM, Kenney SC, and Greijer AE. 2012. Epstein-Barr virus transcription activator R upregulates BARF1 expression by direct binding to its promoter, independent of methylation. J. Virol. 86:11322-11332.
  • Robinson AR, Kwek SS, Hagemeier SR, Wille CK, and Kenney SC. 2011. Cellular transcription factor Oct-1 interacts with the Epstein-Barr virus BRLF1 protein to promote disruption of viral latency. J. Virol. 85:8940-8953.