Dominik Hoelper

Dominik Hoelper
Biochemical and mechanistic understanding of the H3.3-specific histone chaperone DAXX

Years at WID

2014 - present


Dominik Hoelper is a graduate student in the 2013 cohort of the Integrated Program of Biochemistry (IPiB).


  • B.S., Molecular Biomedicine, University of Bonn, Germany
  • M.S., Life and Medical Sciences with distinction, University of Bonn, Germany


  • Boehringer Ingelheim Fonds (BIF) predoctoral fellowship
  • Research Internships in Science and Engineering (RISE) fellowship awarded by the German Academic Exchange Service (DAAD)

Selected Publications

  • Lu C, Jain SU, Hoelper D et al., Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Science. 2016 May 13;352(6287):844-49
  • Jayaram H*, Hoelper D*, Jain SU, Cantone N, Lundgren SM, Poy F, Allis CD, Cummings R, Bellon S, Lewis PW., S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine-9-to-methionine mutation on histone H3., Proc Natl Acad Sci. 2016 May 16 (Early Edition), *co-first authors
  • Gaebler A, Milan R, Straub L, Hoelper D, Kuerschner L, Thiele C. Alkyne lipids as substrates for click-chemistry based in vitro enzymatic assays. J. Lipid Res, 54(8), 2282-90 (2013)
  • Thiele C, Papan C, Hoelper D, Kusserow K, Gaebler A, Schoene M, Piotrowitz K, Spandl J, Lohmann D, Stevanovic A, Shevchenko A, Kuerschner L. Tracing fatty acid metabolism by click-chemistry. ACS Chemical Biology, 7(12), 2004-11 (2012)