Michael Murrell

Michael Murrell
Physics and Synthesis of Soft, Active and Biological Matter

Years at WID

2014 - present

About

Michael Murrell is from the north side of Milwaukee, WI.

Education

  • B.S., Biomedical Engineering, Johns Hopkins University
  • Ph.D., Bioengineering, MIT
  • Postdoc, Institut Curie/University of Chicago

Research Description

Living cells generate and transmit mechanical forces over diverse time-scales and length-scales to determine the dynamics of cell and tissue shape during homeostatic and pathological processes, from early embryonic development to cancer metastasis. These forces arise from the cell cytoskeleton, a scaffolding network of entangled protein polymers driven out-of-equilibrium by enzymes that convert chemical energy into mechanical work. However, how molecular interactions within the cytoskeleton lead to the accumulation of mechanical stresses that determine the dynamics of cell shape is unknown. Furthermore, how cellular interactions are subsequently modulated to determine the shape of the tissue is also unclear. To bridge these scales, our group uses a combination of experimental, computational and theoretical approaches. On the molecular scale, we use active nematic liquid crystals as a framework to understand how mechanical stresses are produced and transmitted within the cell cytoskeleton. On the scale of cells and tissues, we abstract these stresses to surface tensions in a liquid droplet and draw analogies between the dynamics of droplet wetting (and dewetting) and the shape dynamics of cells and simple tissues. Together, we develop comprehensive descriptions for how cytoskeletal stresses translate to the physical behaviors of cells and tissues with significant phenotypic outcomes such as wound healing and cancer metastasis.

Affiliations

  • American Physical Society
  • American Society for Cell Biology

Honors

  • MIT Presidential Fellow
  • NIH Biotechnology Training Grant

Selected Publications

  • I. Linsmeier, S. Banerjee, P. Oakes, W. Jung, T. Kim, M. Murrell, Disordered Actomyosin Networks are Sufficient to Produce Cooperative and Telescopic Contractility (2016), Nature Communications, Vol 7, Article Number: 12615, pp 1-9, doi:10.1038/ncomms12615
  • Michael P. Murrell, Raphaël Voituriez, Jean-François Joanny, Pierre Nassoy, Cécile Sykes& Margaret L. Gardel (2014), Liposome Adhesion Generates Traction Stress, Nature Physics, Vol 10, 163-169
  • Michael P. Murrell, Patrick W. Oakes, Martin Lenz & Margaret L. Gardel (2015), Forcing cells into shape: the mechanics of actomyosin contractility, Nature Reviews Molecular Cell Biology, Vol 16, 486-498
  • M. Murrell, M. Gardel, F-actin Buckling Coordinates Contractility and Severing in a Biomimetic Actomyosin Cortex, PNAS, Vol 109, no. 51, 2012
  • M. Murrell*, L.L. Pontani*, K. Guevorkian, D. Cuvelier , P. Nassoy and C. Sykes (2011), Spreading Dynamics of Biomimetic Actin Cortices, Biophysical Journal, Vol 100, Issue 6, pp 1400-1409
  • M. Murrell, R.D. Kamm and P.T. Matsudaira (2011), Substrate Viscosity Enhances Correlation in Epithelial Cell Motion, Biophysical Journal, Vol 101, Issue 2, pp 297-306 M. Socolovsky*,
  • M. Murrell*, Y. Liu, R. Pop, E. Porpiglia, A. Levchenko (2007), Negative Autoregulation by FAS mediates robust erythropoiesis, PLOS Biology, Vol 5, Issue 10, pp 2297-2311