Tiago Fernandes

Stem cell pluripotency and differentiation


Portuguese, researcher, teacher


 PhD, Tecnico, U.Lisboa, Portugal

Research Description

Dr. Tiago G. Fernandes is currently an assistant professor at Instituto Superior Técnico, University of Lisbon, and a research scientist at the Institute for Bioengineering and Biosciences, Lisbon, Portugal. He also holds a double affiliation with The Discoveries Centre for Regenerative and Precision Medicine, at Instituto Superior Técnico. His work is focused on providing an integrated platform that brings together engineering and biology in order to accelerate progress towards designing the stem cell fate and its microenvironment. The development of artificial cellular niches for studying the mechanisms that affect human stem cell pluripotency is of foremost importance and represents a major goal of my research. Human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells are used as model systems to establish in vitro artificial microenvironments that better mimic the extracellular environment. In addition to the influence of mechanical and matrix-related responses, the effects of microenvironmental conditions (e.g. small molecules and growth factors) have been extensively studied due to their capacity to modulating intracellular pathways. This systems-based approach is expected to contribute for the development of innovative cell culture models that better reflect in vivo function, and the final goal is to generate cells and tissues to advance our understanding of biology and tissue regeneration, which will lead to further development of cell-based therapies.


Instituto Superior Técnico, U. Lisboa, Portugal