Xianghui Xu

Xianghui Xu
Bioinspired macromolecular and supramolecular strategy for advanced biomaterials.

Years at WID

2018 - present

Education

  • B.S., Functional Biomaterials, Beijing University of Chemical Technology, Beijing, China
  • Ph.D., Macromolecular Chemistry and Physics, Sichuan University, Chengdu, China

Research Description

Prof. Dr. Xu is focusing on the development of precise macromolecular and supramolecular strategies for developing biomimetic nanomaterials and new therapeutic agents.

  1. Bioinspired materials mimicking structures and functions of natural system (e.g., viruses and cells) for biomedical applications.
  2. New dendrimeric peptide drugs for high-efficiency tumor apoptosis and autophagy induction, and their pharmacological mechanisms.
  3. Multifunctional nanomaterials as theranostic nanoplatforms for treatment of various diseases.

Selected Publications

  • Membrane-Breaking Nanoparticles with Tumor-Activated Cell-and-Tissue Dual-Penetration Conquer Impermeable Cancer. Adv. Mater. 2018, 30, 1707240. [Corresponding Author]
  • Tumor-adapting and tumor-remodeling AuNR@dendrimer-assembly nanohybrids overcome impermeable multidrug-resistant cancer. Mater. Horiz. 2018, DOI: 10.1039/c8mh00694. [Corresponding Author]
  • Tumor-Specific Multiple Stimuli-Activated Dendrimeric Nanoassemblies with Metabolic Blockade Surmount Chemotherapy Resistance. ACS Nano 2017. 11, 416–429. [Corresponding Author]
  • Supramolecular PEGylated Dendritic Systems as pH/Redox Dual-Responsive Theranostic Nanoplatforms for Platinum Drug Delivery and NIR Imaging. Theranostics 2016, 6(9), 1293-1305. [Corresponding Author]
  • Bioinspired Design of Stereospecific D-Protein Nanomimics for High-Efficiency Autophagy Induction. Chem. Mater. 2017, 29, 7658–7662. [Corresponding Author]
  • Bioinspired Therapeutic Dendrimers as Efficient Peptide Drugs Based on Supramolecular Interactions for Tumor Inhibition. Angew. Chem. Int. Ed. 2015, 54, 4289-4294. [Corresponding Author]
  • Virus-Inspired Mimics Based on Dendritic Lipopeptides for Efficient Tumor-Specific Infection and Systemic Drug Delivery. Adv. Funct. Mater. 2015, 25, 5250-5260. [Corresponding Author]
  • Bio-Inspired Supramolecular Hybrid Dendrimers Self-Assembled from Low-Generation Peptide Dendrons for Highly Efficient Gene Delivery and Biological Tracking. ACS Nano 2014, 8, 9255-9264. [First Author]
  • Smart Nanovehicles Based on pH-Triggered Disassembly of Supramolecular Peptide-Amphiphiles for Efficient Intracellular Drug Delivery. Small 2014, 10, 1133-1140. [First Author]
  • Cooperative Hierarchical Self-Assembly of Peptide Dendrimers and Linear Polypeptides into Nanoarchitectures Mimicking Viral Capsids. Angew. Chem. Int. Ed. 2012, 51, 3130-3133. [First Author]