Working to understand the fundamental mechanisms of chromatin-based gene regulation. The lab studies how various chromatin factors are recruited to chromatin to “read” and ‘translate” epigenetic information into differential gene expression patterns under normal growth and development as well as stress conditions.
The main scientific focus of the lab is in defining how the epigenome controls cell identity. We want to know how non-genetic information controls functional specialization of a cell and use this knowledge to direct efficient conversion of desired cell types with the ultimate goal of improving stem cell based therapy.
Investigating the mechanism and biological function of reversible protein modifications involved in modulating signal transduction, chromatin dynamics, and gene activation and addressing the “Histone Code” hypothesis by beginning to understand histone modification signaling code and its mechanisms and regulation.
The Multi-Omics Hub will focus on the use of big data about the genes, microorganisms, and metabolites to understand biological systems. WID’s expertise makes it an ideal home for the Epigenetics Initiative for the large campus community that studies the epigenome, and as such WID will organize meetings, seminars, mutli-PI …
Xuehua Zhong recently received an outstanding investigator award from NIH via the Maximizing Investigators’ Research Award (MIRA) mechanism to support her research. She talked about how she uses plants to study epigenetics in an interview with Grow magazine.
The podcast “Is DNA the Basis for all Life in the Universe?” produced by The Naked Scientists, an affiliate of the BBC at Cambridge University features John Denu speaking of his recent findings on how the gut microbiome affects DNA expression.
Systems Biology researcher Sushmita Roy is leading an effort putting computational methods to work characterizing the gene regulatory networks responsible for cell differentiation.
Xuehua Zhong speaks to Hope Kirwan of Wisconsin Public Radio about leaf senescence.
The upshot of the study from researchers in the Epigenetics theme at WID is another indictment of the so-called Western diet, high in saturated fats, sugar, and red meat.
Xuehua Zhong describes an epigenetic mechanism behind plant aging for the first time in a ground-breaking new paper in eLife.
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WID Principal Investigator Peter Lewis honored for work on modifying histones to treat cancer.
Epigenetics researcher Peter Lewis has linked a histone mutation to a rare pediatric bone cancer, an important step in understanding and treating more common cancers.
The Epigenetics theme at WID is putting mass spectrometry to use in new ways with specialized workflows designed to uncover the mysteries of chromatin.
John Denu, Epigenetics Theme leader, keeps UW-Madison on top of research in epigenetics.
Short circuiting tumors via Epigenetics drives Lewis Lab’s research.