John Denu
Professor, Multi-Omics Leader
Epigenetic chromatin changes that regulate cell signaling and metabolism
Tag: -omics
-Omics research includes fields such as proteomics, genomics, epigenomics, and metabolomics and refers to the totality of a subject: all constituent parts considered collectively.
WID researchers are working to manage and utilize the massive amounts of data associated with -omics research to understand and inform gene regulation, cellular reprogramming, precision medicine, and complex biological systems.
WID is home to the Multi-Omics Hub.
ZhengZheng (Jane) Tang
Assistant Professor
Developing statistical methods and computational tools for high-throughput omics data.
Multi-Omics Hub
The Multi-Omics Hub will focus on the use of big data about the genes, microorganisms, and metabolites to understand biological systems. WID’s expertise makes it an ideal home for the Epigenetics Initiative for the large campus community that studies the epigenome, and as such WID will organize meetings, seminars, mutli-PI …
Rupa Sridharan
Associate Professor
Epigenetic control of cell identity in pluripotency, development and disease
Inference and Evolutionary Analysis of Genome-Scale Regulatory Networks in Large Phylogenies
In a paper in Cell Systems, Sushmita Roy and colleagues develop a probabilistic graphical model-based method, multi-species regulatory network learning that uses a phylogenetic framework to infer regulatory networks in multiple species simultaneously.
Randolph Ashton
Associate Professor
Engineering brain and spinal cord tissues ex vivo using human pluripotent stem cells
John Yin
Vilas Distinguished Achievement Professor
Forecasting of virus-host growth and infection spread; physical and chemical origins of life
Tools for Discovery: Carla Michini
Tools for Discovery is a regular profile series that inspects the computer programs, gadgets, and methods behind WID’s ideas and discoveries.
Tools for Discovery: Erik Wright
Tools for Discovery is a regular profile series that inspects the computer programs, gadgets and methods behind WID’s ideas and discoveries.
Deciphering Gene Regulatory Networks
Systems Biology researcher Sushmita Roy is leading an effort putting computational methods to work characterizing the gene regulatory networks responsible for cell differentiation.
Gut’s Microbial Community Shown to Influence Host Gene Expression
The upshot of the study from researchers in the Epigenetics theme at WID is another indictment of the so-called Western diet, high in saturated fats, sugar, and red meat.
Understanding the Immune System with Machine Learning
Systems Biology researchers Deborah Chasman and Sushmita Roy are using machine learning to identify virus and pathogenicity-specific regulatory networks which may guide the design of effective therapeutics for infectious diseases. The work is described in a recent paper in PLOS Computational Biology.
Gene Regulatory Mutation Linked to Rare Childhood Cancer
Epigenetics researcher Peter Lewis has linked a histone mutation to a rare pediatric bone cancer, an important step in understanding and treating more common cancers.
Mass Spectrometry Brings Epigenetics into Focus at UW
The Epigenetics theme at WID is putting mass spectrometry to use in new ways with specialized workflows designed to uncover the mysteries of chromatin.
Epigenetics Research at UW-Madison Ready for the Next Step
John Denu, Epigenetics Theme leader, keeps UW-Madison on top of research in epigenetics.
New journal to publish research by UW–Madison undergraduates
Eddie Ruiz and Stephanie Seymour — both UW-Madison juniors affiliated with WID researchers — are launching The Journal of Undergraduate Science and Technology for the UW Madison campus
DECIPHER: harnessing local sequence context to improve protein multiple sequence alignment
Researchers at WID are continually publishing premier research in top publications. Here, we feature some of the most important and transformative scientific publications from our community.
The Natural Order and Divine Law of Optimization
Michael Ferris and Stephen Wright, principal investigators in the WID Optimization Theme comment on New York Times Magazine article “A Sucker is Optimized Every Minute”.
Harvesting the Power of Big Data in Agriculture
Harvesting data and harvesting crops? There’s an app for that.
Tools for Discovery: Ben Shapiro
WID collaborator and Tufts University researcher Ben Shapiro taps into technology to make learning fun. Read more about why compassion is his ultimate tool for discovery.
Tools for Discovery: Rock Mackie
Thomas “Rock” Mackie, WID partner at the Morgridge Institute for Research, shares his essentials for success in engineering. Topping his list? Excellent collaborators and team members.
Scientists Create Road Map to Metabolic Reprogramming for Aging
A recent WID study creates a better understanding of how cells are “reprogrammed” when an organism eats fewer calories.
Student Computer Game Simulates Biofuel Production
A partnership between WID and the Great Lakes Bioenergy Research Center uses data and gaming to crack tough research questions.