Tag: tissue engineering
The promise of tissue engineering stretches the limits of our imagination.
Biotechnology in general, and stem cell research in particular, has made great strides in spurring the growth (and re-growth) of specific human cell types. But cells alone cannot replace human tissue. Cells need scaffolds to serve as structural guides while growing into useful tissues or life-saving drug delivery systems.
Cell-scale scaffolds share similarities with building-scale scaffolds used in construction projects. Viable scaffolds allow for the mass transport of oxygen and nutrients. These scaffolds can direct the growth of cells migrating from nearby tissue or provide a foothold for new tissue growth. This directed growth could be used to replace destroyed nerves or heal fractured bones, damaged blood vessels, or parts of diseased organs.
Tissue engineering researchers at WID are laying the research foundation for these transformative scaffolding technologies. Ultimately, their work aims to heal damaged tissues with remarkable speed and minimal complications.
By working at the intersection of biotechnology and nanotechnology, tissue engineering researchers are building a library of scaffolding materials and cost-effective, mass-production methods that will work for a variety of cell types used in a wide range of in-body applications.
Nikolai Fedorchak
Laboratory Manager
Research concerning Human Neural Organoids, Tissue Engineering, and CNS Development. Facilitate various administrative duties.
Grant Funds Creation of Spinal Tissue from Scratch in UW-Madison Lab
WKOW Channel 27 highlights Randolph Ashton’s NSF grant to create blank model for spinal cells.
Randolph Ashton
Associate Professor
Engineering brain and spinal cord tissues ex vivo using human pluripotent stem cells
Parsley and other plants lend form to human stem cell scaffolds
Writing March 20 in the journal Advanced Healthcare Materials, WID Fellow William Murphy describes the use of a variety of plants to create an efficient, inexpensive and scalable technology for making tiny structures that could one day be used to repair muscle, organs and bone using stem cells.
With Human Spinal Cord Tissues in a Dish, UW-Madison Engineer Aims to Accelerate Disease Treatment
Randolph Ashton, assistant professor of biomedical engineering in the Bionates Theme at WID, received a prestigious National Science Foundation CAREER Award for advancing tissue engineering of the human spinal cord.
Can Artery ‘Banks’ Transform Vascular Medicine?
BIONATES Lih-Sheng “Tom” Turng works in tandem with Morgridge Institute for Research scientist James Thomson to create scaffolds for small diameter arteries.
Smart Cancer Therapies: Teaching the Body’s Own T-cells to Attack Tumors
Kris Saha with colleagues David Beebe and Christian Capitini aim to develop improved methods for making CAR T-Cells with a two-year grant from the NSF.
Tools for Discovery: Srikanth Pilla
Tools for Discovery is a monthly profile series that inspects the computer programs, gadgets and methods behind WID’s ideas and discoveries.
Professor Lih-Sheng (Tom) Turng: Advancing Microcellular Polymers
Thanks to the research of Professor Lih-Sheng (Tom) Turng, plastics can have applications in products ranging from eyeglass lenses to engineered tissues.
High-Content Analysis of CRISPR-Cas9 Gene-Edited Human Embryonic Stem Cells
Kris Saha and colleagues from the BIONATES Theme detail a new approach that can refine gene editing in this month’s issue of Stem Cell Reports.
Alleles in Allegro: Accelerating the Pace with HCA
Kris Saha, Assistant Professor in the BIONATES theme, is featured in a Genetic Engineering & Biotechnology News article for his work with High Content Analysis.
UW-Madison study: ‘Tissue chips’ could screen drugs, chemicals
WID scientists David Page and Bill Murphy were part of a study using stem cells to create model neural tissues to screen for toxicity.
Tools for Discovery: Max Salick
Tools for Discovery is a monthly profile series that inspects the computer programs, gadgets and methods behind WID’s ideas and discoveries.
Cracking the (Zip)code of Neural Cells
Published today in Stem Cell Reports, researchers led by Randolph Ashton and Ethan Lippmann present a unifying protocol to create neural stem cells from diverse regions of the hindbrain and spinal cord.
With New Tools, Researchers Aim to Broaden Understanding of Toxins’ Effect on the Body
Through an Environmental Protection Agency initiative, WID researchers are playing a key role in learning how toxins impact human health and the environment.
Flipping the Switch on Pluripotent Stem Cells
Rupa Sridharan, Assistant Professor of Cell and Regenerative Biology at Wisconsin Institute for Discovery explains how she increased reprogramming efficiency to get pluripotent stem cells.
Beautiful Data: Cell Biology Yields Microcosms of Art
Peering through lenses, researchers are finding award-winning fluorescent landscapes, artful strokes, and a multitude of cell shapes and signals.
Spreading the Benefits of Stem Cell Advances
Researchers are working on ways to standardize how stem cells are harnessed to advance therapies and study disease.
Harvesting the Power of Big Data in Agriculture
Harvesting data and harvesting crops? There’s an app for that.
WID Stem Cell Advance Yields Mature Heart Muscle Cells
WID and UW-Madison researchers are finding ways to program stem cells to behave more like heart muscle cells.
WID and UW-Madison Partner in National Effort to Retool U.S. Manufacturing
WID and UW-Madison are national partners for the newly formed Digital Lab for Manufacturing, a White House initiative to develop digital tools to enhance manufactured products, from conception to production.
“Greener” Aerogel Technology Holds Potential for Oil and Chemical Clean-Up
A WID team examines greener materials to offer a cheaper and more sustainable way to absorb oil from water.
Tools for Discovery: Kris Saha
What are your tools for discovery? BIONATES researcher Kris Saha’s tools focus on personal communication, examining problems from multiple vantage points and — dare we say — a penchant for procrastination.