Friday, May 21
11:30 am – 1:30 pm CDT
The WID Symposium Poster Sessions are hosted on Congregate (click here for tips on using Congregate). This page includes a gallery of all posters so that you can browse them at your leisure before, during, and after the symposium. A template for WID posters, should you wish to use one, is available here.
Browse this folder in Google Drive here.
|1||Hayley Boigenzahn||Measures and mathematical models of prebiotic peptide formation
Studying the origin of life can help us better understand our own biology and potentially design highly adaptable systems to use as platforms for molecular discovery. It can also help us recognize the potential for life on other worlds by recognizing what molecules allowed life to form on our own planet.
|2||Em Craft||DiscoverIT, UW-Madison, and WID Provide Your IT Services
|3||Michael Ferris||wivDM: covid vaccine allocation modeling for Wisconsin
Wisconsin made a remarkable about-face in two months, shooting up state rankings to become a leader in vaccinations. Ninety percent of the doses delivered to Wisconsin have been administered. How? Rather than a focus on high-volume sites, the state sent vaccines to public and private health-care providers, in an approach one state health department official likened to an even spread of peanut butter. This poster helps explain the model behind that allocation.
|4||Nisha Iyer||Probing Spinal Cord Diversity With Human Stem Cell Differentiation and Single Cell RNA-Sequencing
The spinal cord contains billions of neurons, with a huge diversity of subtypes enabling sensory, proprioceptive, and motor function. However, current human stem cell-based in vitro models and prospective cell transplantation therapies fail to reflect the significant regional specificity of spinal cells.
|5||Julian Katz-Samuels||An Empirical Process Approach to the Union Bound: Linear and Combinatorial Bandits
This paper proposes near-optimal algorithms for the pure-exploration linear bandit problem in the fixed confidence and fixed budget settings. Leveraging ideas from the theory of suprema of empirical processes, we provide an algorithm whose sample complexity scales with the geometry of the instance and avoids an explicit union bound over the number of arms.
|6||Alexis Lawton||Revealing dynamic protein acetylation across subcellular compartments
Acetylation of the Œµ-amino of lysine residues is a widespread, reversible post-translational modification that regulates many cellular functions, including protein-protein interactions, protein-DNA interactions, cellular localization, protein stability, and enzymatic activity. Historically, the first well-characterized example of acetylation was found on histone tails, but more recent proteomics analyses have identified thousands of acetylation sites on non-histone proteins.
|7||Sarah Leichter||Substrate deformation regulates DRM2-mediated DNA methylation in plants
DNA methylation is a major epigenetic mechanism that critically regulates transposable element silencing and genomic stability. In plants, DOMAINS REARRANGED METHYLTRANSFERASE 2 (DRM2) preferentially mediates CHH (H= C, T, A) methylation, a substrate specificity distinct from that of mammalian DNA methyltransferases. However, the underlying mechanism is unknown.
|8||Shruthi Magesh||Genetic determinants of surface colonization by abundant rhizosphere bacterium Flavobacterium johnsoniae
The rhizosphere encompasses the diverse community of microbes living on the surface of plant roots and in their vicinity in soil. This community is a key determinant of plant health because it provides nutrients, mediates disease, and influences plant development. Members of the gram-negative genus, Flavobacterium, are abundant in the rhizosphere and soil.
|9||Ellen Morgan||Implementing degron technology to study the role of histone demethylases in pluripotency maintenance
Members of the KDM3 histone demethylase family, KDM3A and KDM3B, play an essential role in maintaining embryonic stem cell (ESC) pluripotency. They appear functionally redundant in this role, as only simultaneous depletion of both factors results in loss of self-renewal and cell viability in ESCs. Despite their necessity, the specific mechanism by which KDM3B and KDM3A help maintain pluripotency remains uncharacterized.
|10||Katie Mueller||Single Cell Profiling to Define Biomarkers of Photoreceptor Dysfunction after Gene Editing within human PSC-Derived Organoids
Screening for adverse events is essential for the development of safe genome editing therapies. Here we propose to develop a generalizable and scalable approach to define biomarkers for adverse events after delivery of a genome editor.
|11||Kushin Mukherjee||Mapping a low - dimensional space of color - concept associations
People systematically associate colors and concepts, a phenomenon that can either help or hinder the interpretation of color in information visualizations. For instance, by applying optimization algorithms on color concept association ratings, one can create palettes that are easily interpretable without legends (Schloss et al., 2018). Yet such optimization requires the designer to quantify associations between each concept and a large range of colors, to avoid the conflicts that arise when multiple concepts evoke the same strongest associates.
|12||Zhen Peng||Seed-dependent Autocatalytic Cycles organize complex reaction networks underlying abiogenesis
Life is the canonical example of a complex system, consisting of many and diverse chemical components organized in specific manners, and some of these components are too large and complex to emerge spontaneously from abiotic materials. In contrast, the abiotic environment, which life feeds on and originated from, is much simpler and less organized. Such a gap between biotic and abiotic worlds, and the lack of direct observation of abiogenesis, make origin of life one of the hardest scientific questions.
|13||Alex Plum||Spatial Structure in Autocatalytic Chemical Ecosystems at the Origins of Life
At the origin of life, autocatalytic cycles may have formed chemical ecosystems and evolved, providing the scaffolding for later stages in the emergence of life. How exactly evolvability can emerge in out-of-equilibrium chemical processes remains an open question. Autocatalytic cycles, whose constituent chemicals collectively catalyze their own continuous recreation, may exhibit limited evolvability when situated in the right sort of spatial structure.
|14||Yiming (Amy) Qin||Deficiency in Sirtuin3 rewires mitochondrial metabolism and increases maximum lifespan under caloric restriction
CR is a widely studied regimen in mice that robustly extends health span and lifespan. Previous work revealed that CR stimulates Sirtuin 3 (SIRT3) expression, and through deacetylation of mitochondrial enzymes enhances metabolic flux of pathways often dysregulated in aging and age-related disorders. Here, we set out to investigate the importance of SIRT3 in CR-mediated longevity.
|15||Demitri Shotwell||Turng Group - Polymer Processing
Through smart manufacturing techniques, the processing of difficult and unique materials, novel tooling, and novel processing methods we determine ways to improve plastic parts and plastic manufacturing. This work can be scaled up for industrial applications and offer insights in the theoretical understanding of polymers and rheology. Our work aims to improve our understanding of polymers and directly applies to every-day products such as single use plastic silverware and to high-performance products such as optical components in cell phones. In improving polymer processing we can increase part quality, reduce cost, and reduce waste in manufacturing.
|16||Akhilesh Soni||Integer Programming for High Rank Matrix Completion
Finding a low-rank representation of high-dimensional data is a fundamental problem in data science. In the High-Rank Matrix Completion (HRMC) problem, we are given a collection of n data points where each of the data points is observed only on a subset of its coordinates, and the points are assumed to lie in the union of a small number of low-dimensional subspaces. The goal of HRMC is to recover the missing elements of the data points under these assumptions.
|17||Alana Stempien||Micropattern Platform Promotes Extracellular Matrix Remodeling by Human PSC-derived Cardiac Fibroblasts and Enhances Contractility of Co-cultured Cardiomyocytes
In native heart tissue, cardiac fibroblasts provide the structural framework of extracellular matrix (ECM) while also influencing the electrical and mechanical properties of cardiomyocytes. Recent advances in the field of stem cell differentiation have led to the availability of human pluripotent stem cell-derived cardiac fibroblasts (iPSC-CFs) in addition to cardiomyocytes (iPSC-CMs).
|Data Science Hub
The Data Science Hub in the Wisconsin Institute for Discovery collaborates closely with the Data Science Institute to provide data science training and implementation across campus. The Data Science Hub executes a mission for community engagement and learning opportunities for campus researchers through a variety of services, including:
- consultations with Data Science Facilitators who can recommend learning pathways and project strategies, and liaise contacts with collaborators and data science experts
|19||Ross Tredinnick||3D Scanning for Automobile Insurance Damage Assessment
In this project, we are exploring the use of commercially available mobile devices, such as the iPad Pro 2020, and iPhone 12 Pro, both newly containing embedded LiDAR (Light Detection and Ranging) sensor technology, to 3D scan automobiles for insurance documentation and assessment purposes. 3D Scanning is the process of rapidly creating a 3D model of a physical, real-world object.
|20||Chenglong Yu||Studies on Small-Diameter Vascular Grafts
Deaths caused by cardiovascular diseases have been increasing over the globe. Vascular transplantation is the most effective means of treating such diseases. However, the availability of healthy and mechanically robust tissue sources is limited, which has increased the necessity of artificial vascular graft development. Currently, many commercial synthetic materials such as Dacron and extended-polytetrafluoroethylene (ePTFE) have been successfully used for large-diameter (inner diameter>6mm) artificial blood vessels. While none of these materials has been proven suitable for the fabrication of small-diameter (inner diameter<6mm) vascular grafts due to thrombus formation and intimal hyperplasia. Endothelium consisting of a continuous monolayer of endothelial cells (ECs) is the innermost layer of native blood vessels and involved in multifaceted blood vessel activities, such as inflammation, fibrinolysis, hemostasis, and extracellular matrix (ECM) production owing to direct contact with blood. Vascular basement membrane (VBM) is a thin layer of fibrous extracellular matrix linking endothelium, and it plays a crucial role in anchoring down the endothelium to its loose connective tissue underneath.
|21||Yunyi Shen||Bayesian Conditional Auto-Regressive LASSO Models to Learn Sparse Networks with Predictors
Inferring a graphical structure with nodes for multiple responses and predictors is a fundamental statistical problem with broad applications from microbiome, ecology to genetics. While a multiresponse linear regression model seems like a straight-forward solution, we argue that treating it as a graphical model is flawed and caution should be taken because the regression coefficient matrix does not represent the adjacency matrix between response and predictor nodes that encodes conditional dependence.
|22||Yue Xie||Projected Newton Methods for Bound-Constrained Optimization
We propose two methods based on the projected Newton methods for solving bound-constrained optimization problems. The first method is a scaled variant of Bertsekas's two-metric projection method. The second is a projected Newton-Conjugate Gradient (CG) method. These algorithms are designed to possess both practicality and worst-case complexity guarantees matching the best known in literature. We illustrate the competitive performance of the second method against other solvers on nonnegative matrix factorization (NMF).
|23||Sarah Miller||TINY EARTH: A network of students crowdsourcing antibiotic discovery from soil bacteria
Tiny Earth is an international network of students crowdsourcing antibiotic discovery from soil with the goal of addressing a public health crisis, antibiotic resistance. Visit our poster to learn how we pivoted the wet-lab course to online due to COVID-19, how we incorporated AJEDI (antiracism, justice, equity, diversity, and inclusion) principles into the curriculum, what new outreach materials we developed with PBS Wisconsin, what new discoveries we found in the lab, and more.
|24||Travis Tangen||Expand your Impact: Collaborate with the Meet the Lab team
Meet the Lab is a collection of educational resources for middle school science classrooms, and is a collaboration between PBS Wisconsin Education, Wisconsin Institute for Discovery, Wisconsin Alumni Research Foundation, and the Morgridge Institute for Research.
This collection introduces students to relevant real-world issues, cutting edge research, and the human element—the people working together to research, innovate, and solve problems using science.
Learn about a new web resource from WID to help you get what you need to be successful at WID and UW: widkipedia.wid.wisc.edu
Browse this folder in Google Drive here.