We are an inclusive group of researchers that endeavor to understand how different phenotypes can be generated from a single genome. The collection of UW-Madison researchers offers a diverse perspective on the growing fields of epigenetics and chromatin-based regulation of gene expression. This website is intended to share information about events, faculty and resources available within our epigenetics community. This rich research community also provides an excellent training environment for current and prospective Graduate students and Post-doctoral trainees.

The goals of the UW Epigenetics Program are to investigate, educate, and promote how the epigenome contributes to phenotype and homeostasis. The Program functions as a UW-Madison campus community to foster interdisciplinary collaborations with basic and translational research in epigenetics at the molecular, systems and organism level. Members of this community represent diverse but complementary disciplines that all seek to understand how the epigenome, in collaboration with the genome, control biological and molecular fate. Importantly, this understanding will lead to new insights into how humans and other organisms control their own epigenetic destiny by lifestyle, diet and other environmental factors.

Goals

  • Create and maintain a dynamic community that effectively shares expertise, skills and reagents to rapidly advance research in the broad field of epigenetics.
  • Enrich trainee (student and post-doc) experiences by engaging the diverse UW-Madison research community.
  • Establish a culture that creates opportunities to develop non-traditional collaborations.
  • Co-sponsor relevant outside seminar speakers.
  • Participate in actionable items that accelerate epigenetics research: (i)Writing grants for Program Projects and shared instrumentation (ii)Participation in workshops.
  • Develop courses/workshops that enhance understanding of epigenetic/chromatin.
  • Execute annual epigenetics retreat.
  • Facilitate monthly Epigenetics Group Discussions/seminars.

Faculty

Reid Alisch
Reid AlischPsychiatry
Defining the role of DNA methylation in psychiatric disorders
Richard Amasino
Richard AmasinoBiochemistry
Regulation of plant development; mechanisms of floral induction
Alan Attie
Alan AttieBiochemistry
Genetics of diabetes, beta-cell biology, lipid metabolism, and diet outcome
Anthony Auger
Anthony AugerPsychology
Epigenetic programming of the juvenile social brain
Emery Bresnick
Emery BresnickCell and Regenerative Biology
Mechanisms governing stem and progenitor cell transitions
Qiang Chang
Qiang ChangMedical Genetics and Neurology
DNA methylation-dependent epigenetic regulation of brain functions
Joshua Coon
Joshua CoonMolecular Chemistry
Developing global analysis technologies for epigenetic research
John Denu
John DenuBiomolecular Chemistry
Mechanisms that link metabolism and epigenetic information
Rick Eisenstein
Rick EisensteinNutritional Sciences
Effect of iron and oxygen on gene regulation
Anthony Gitter
Anthony GitterBiostats & Med Informatics
Predicting transcription factor activity from epigenetics, expression
Melissa Harrison
Melissa HarrisonBiomolecular Chemistry
Early embryonic genome reprogramming and transcriptional activation
Bermans Iskandar
Bermans IskandarNeurosurgery
The role of epigenetic mechanisms in CNS injury and repair
David Jarrard
David JarrardUrology
Epigenetics in cancer development and interactions with environment
Jiming Jiang
Jiming JiangHorticulture
Transcription and epigenetic modifications of centromeric chromatin
Eric Johannsen
Eric JohannsenInfectious Diseases
The molecular biology of Epstein-Barr virus (EBV) nuclear proteins, their role in the virus lifecycle and the pathogenesis of EBV associated malignancies.
Rob Kalejta
Rob KalejtaMolecular Virology
Epigenetic control of human cytomegalovirus latency
Nancy Keller
Nancy KellerMedical Microbiology
Epigenetic regulation of fungal secondary metabolism
Hasan Khatib
Hasan KhatibAnimal Sciences
Development of noninvasive biomarkers of embryo development
Youngsook Lee
Youngsook LeeCell and Regenerative Biology
Epigenetic Mechanisms in Development and Cancer
Sushmita Roy
Sushmita RoyBiostatistics and Medical Informatics
Predictive models of cell-type specific gene expression
Lixin Rui
Lixin RuiDepartment of Medicine
Gene regulation by JAK kinases through targeting histone H3
Lloyd Smith
Lloyd SmithChemistry
Hybridization Capture of Chromatin-Associated Proteins for Proteomics
Rupa Sridharan
Rupa SridharanCell and Regenerative Biology
Epigenetics of cell fate change
Michael Sussman
Michael SussmanBiochemistry
Mass spectrometric based methods for measuring protein conformation
John Svaren
John SvarenComparative Biosciences
Epigenomic Reprogramming in Peripheral Nerve Development and Injury
Weiping Tang
Weiping TangSchool of Pharmacy
We design and synthesize histone deacetylase inhibitors
Wei Xu
Wei XuOncology
Epigenetic transcriptional control in breast cancer
Xinyu Zhao
Xinyu ZhaoNeuroscience
Epigenetic regulation of neural stem cells and neurodevelopment

Training

Scientists working in the John Denu Lab

While Epigenetics is not a department/degree program, faculty in multiple departments and degree programs are affiliated with this initiative. Graduate Students interested in Epigenetics can pursue a PhD with any of the listed faculty by applying to the appropriate training program listed on the prospective graduate adviser’s page under the Faculty tab. In addition, many Epigenetics faculty are part of interdisciplinary training programs that offer pre-doctoral student traineeships including the molecular biology training grant (MBTG) and genome sciences training program (GSTP).

Relevant Courses

  • Nutritional Sciences 619  (also Biochem 619) Advanced Nutrition: Intermediary Metabolism of Macronutrient
  • Biochem 630 Cellular Signal Transduction Mechanisms
  • STAT-877 Statistical methods- Molecular biology. How to apply statistical models in biological problems
  • Genetics 677: Epigenetics
  • CS 367  Study of data structures
  • Stats 571  Statistical Methods for Bioscience I
  • Nutri Sci 875  Topics in Proteomic and Genomic Analysis
  • Biochem 620  Eukaryotic Molecular Biology
  • Biochem 601  Protein and Enzyme Structure and Function
  • Biochem 660  Biochemical Techniques
  • BMC 675  Biochemistry of the cell
  • CS 301  Introduction to Data Programming
  • BIOCHEM 612   Prokaryotic Molecular Biology
  • BMC/CHEM 627    Adv/Spec Topics in Mass Spectrometry

Events & News

  • Epigenetics Symposium flyer

Registration now open for 10th annual Epigenetics Symposium

October 14th, 2026|Comments Off on Registration now open for 10th annual Epigenetics Symposium

Registration now open for 10th annual Epigenetics Symposium The Epigenetics of Aging October 26, 2026, 8:30am-5:00pm Wisconsin Institute for Discovery Keynote Speaker: Peter D. Adams, PhD – Director and Professor, Cancer Genome [...]