John Yin

John Yin

John Yin

Theme Leader, Professor, Chemical and Biological Engineering, Systems Biology

Years Active



  • B.A., Columbia College
  • B.S., Columbia University
  • Ph.D., University of California–Berkeley
  • Postdoctoral Fellowship, Max-Planck-Institut fuer Biophysikalische Chemie

Research Description

The goal of systems biology research at the Wisconsin Institute for Discovery is to gain insights into how different organisms cooperate or compete — a problem that will be tackled using approaches and perspectives drawn from diverse fields, including ecology and evolution, physics and chemistry, engineering, mathematics and computer science.

The ultimate aim is to advance models that can predict the likelihood that a microbe can survive and flourish given its environmental surroundings, and to promote human health through effective management of microbe-host interactions.


  • Robert Emmett Dolan Prize, supporting cello studies at Juilliard School of Music, New York, 1978-83
  • Alexander von Humboldt Fellow, 1988
  • NSF Young Investigator Award, 1994
  • NSF Presidential Early Career Award for Scientists and Engineers, 1996

Selected Publications

  • Hensel, S., J.B. Rawlings, and Yin J. 2009. Stochastic Kinetic Modeling of Vesicular Stomatitis Virus Intracellular Growth, Bulletin of Mathematical Biology, in press.
  • Abedon ST, Yin J. 2009. Bacteriophage plaques: theory and analysis. Methods Mol Biol. 501:161-74.
  • Thompson KAS, Rempala GA, Yin J. 2009. Multiple-hit inhibition of infection by defective interfering particles. J Gen Virol 90(Pt 4): 888-99.
  • Zhu Y, Yongky A, Yin J. 2009. Growth of an RNA virus in single cells reveals a broad fitness distribution. Virology 385(1): 39-46.
  • Lim KI, Yin J. 2009. Computational fitness landscape for all gene-order permutations of an RNA virus. PLoS Comput Biol 5(2): e1000283.
  • Zhu Y, Warrick JW, Haubert K, Beebe DJ, Yin J. 2009. Infection on a chip: a microscale platform for simple and sensitive cell-based virus assays. Biomed Microdevices, in press.
  • Haseltine, E. L., J. Yin, and J. B. Rawlings. 2008. Implications of Decoupling the Intracellular and Extracellular Levels in Multi-level Models of Virus Growth. Biotech. Bioeng. 101(4) :811-20.
  • Abedon S.T., Yin J. (2008). Impact of Spatial Structure on Phage Population Growth, in Bacteriophage Ecology: Population Growth, Evolution, and Impact of Bacterial Viruses, Cambridge University Press.
  • Haseltine, E. L., V. Lam, J. Yin, and J. B. Rawlings. 2008. Image-Guided Modeling of Virus Growth and Spread. Bulletin of Mathematical Biology, 70(6):1730-48.
  • John Yin, “Chemical Engineering and Virology: Challenges and Opportunities at the Interface,” AIChE Journal, Sept 2007.