Dynamics of microbial interactions in natural and synthetic microbial communities. The lab develops protocols for quantifying the community dynamics at the phenotypic and genetic levels, and seek simplified theoretical models that reproduce aspects of the experimentally measured dynamics.
Understanding diversity in microbial communities and their role in infectious disease; in particular, the genetic basis for stability of microbial communities, the role of a gut community as a source of opportunistic pathogens, and the soil microbial community as a source of new antibiotics and antibiotic resistance genes.
Investigating how living organisms cooperate or compete in diverse and changing environments. Methods and perspectives are drawn from many fields, including ecology, evolution, molecular biology, physics, chemistry, engineering, mathematics, and computer science. The lab uses data-driven mechanistic and statistical models to predict when microbes or other organisms will persist or perish, with a broad goal of promoting human health through effective management of microbe-host interactions.
The Multi-Omics Hub will focus on the use of big data about the genes, microorganisms, and metabolites to understand biological systems. WID’s expertise makes it an ideal home for the Epigenetics Initiative for the large campus community that studies the epigenome, and as such WID will organize meetings, seminars, mutli-PI …
Handelsman is one of 34 faculty honored with Vilas professorships supported by the estate of professor, Senator, and Regent William F. Vilas.