The advent of the CRISPR-CAS9 technique gives researchers the ability to make precise changes to the DNA of, theoretically, any living organism that has DNA. That precision is particularly meaningful for treatment of diseases caused by well-known faults in genes — otherwise incurable diseases such as sickle cell anemia, the fatal lung disorder cystic fibrosis, and the blindness-causing Leber congenital amaurosis. CRISPR-Cas9 could be a way to prevent or reverse those disorders.

Serendipity reveals new method to fight cancer with T cells

2024-11-22T14:40:55-06:00

A promising therapy that treats blood cancers by harnessing the power of the immune system to target and destroy cancer cells could now treat solid tumors more efficiently. Thanks to a recent study from Dan Cappabianca and Krishanu Saha at the Department of Biomedical Engineering and the Wisconsin Institute for Discovery published in Molecular Therapy – Methods & Clinical Development, Chimeric Antigen Receptor (CAR) T-cell therapy can be improved by altering the conditions the T cells are grown in. And it was all discovered by chance.

Serendipity reveals new method to fight cancer with T cells2024-11-22T14:40:55-06:00

Researchers Develop Advanced Gene Editing Techniques to Boost T Cells in Cancer Treatment 

2024-11-14T20:38:46-06:00

A new study from the Krishanu Saha lab suggests using CRISPR technology to optimize natural immune responses by bioengineering and remodeling T cells. Using a multiplexing technique, the team addresses key challenges in current cancer therapies that could significantly improve treatment outcomes. "We have developed a new way to engineer immune cells to fight cancer more safely and effectively. Think of it as reprogramming the body’s own soldiers (T cells) to recognize and attack cancer cells," says Cappabianca.

Researchers Develop Advanced Gene Editing Techniques to Boost T Cells in Cancer Treatment 2024-11-14T20:38:46-06:00

Saha Lab Alumnae Announced JITC Best Immune Cell Therapies and Immune Cell Engineering Paper

2024-11-14T20:47:46-06:00

Katherine P. Meuller, PhD and Nicole J. Piscopo win with “Production and characterization of virus-free, CRISPR-CAR T cells capable of inducing solid tumor regression”

Saha Lab Alumnae Announced JITC Best Immune Cell Therapies and Immune Cell Engineering Paper2024-11-14T20:47:46-06:00

WID alumnus awarded first AAAS Science & Technology Policy Fellowship in the U.S. Department of the Treasury

2024-11-14T22:45:03-06:00

WID and Saha Lab alumnus, and current postdoc at the Morgridge Institute for Research, Amritava Das anticipates that he will put his engineering and bioscience training to use exploring the sometimes knotty connections between science, national security, and finance.

WID alumnus awarded first AAAS Science & Technology Policy Fellowship in the U.S. Department of the Treasury2024-11-14T22:45:03-06:00

UW Researchers Devise Approach to Treat Rare, Incurable Form of Blindness

2024-11-14T21:58:38-06:00

WID's Kris Saha was among UW–Madison researchers who have published a proof-of-concept method to correct an inherited form of macular degeneration that causes blindness, and that is currently untreatable.

UW Researchers Devise Approach to Treat Rare, Incurable Form of Blindness2024-11-14T21:58:38-06:00

Tiny Capsules Packed with Gene-Editing Tools Offer Alternative to Viral Delivery of Gene Therapy

2024-11-14T22:05:28-06:00

An interdisciplinary pair of WID researchers has developed a new nanocapsule delivery method for delivering the CRISPR-Cas9 gene editing tool. The new system could be used for many types of gene therapies.

Tiny Capsules Packed with Gene-Editing Tools Offer Alternative to Viral Delivery of Gene Therapy2024-11-14T22:05:28-06:00
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