“This platform has the potential to ‘dim’ genome editing in a wide variety of contexts,” says WID faculty, Krishanu Saha, “not only inside the body, but outside the body, and also has implications for fundamental studies of how genome editing occurs in cells, in tissues, and in animals.”
Dr. Krishanu Saha and Dr. Dan Cappabianca are featured on a news clip on Channel3000.
Postdoc Highlight: Kirstan Gimse has taken her passion for investigating neurodegenerative diseases and pushed it into a new area by working as a Genomic Sciences Training Program (GSTP) Postdoctoral trainee with Drs. Sushmita Roy and Krishanu Saha.
A promising therapy that treats blood cancers by harnessing the power of the immune system to target and destroy cancer cells could now treat solid tumors more efficiently. Thanks to a recent study from Dan Cappabianca and Krishanu Saha at the Department of Biomedical Engineering and the Wisconsin Institute for Discovery published in Molecular Therapy – Methods & Clinical Development, Chimeric Antigen Receptor (CAR) T-cell therapy can be improved by altering the conditions the T cells are grown in. And it was all discovered by chance.
A new study from the Krishanu Saha lab suggests using CRISPR technology to optimize natural immune responses by bioengineering and remodeling T cells. Using a multiplexing technique, the team addresses key challenges in current cancer therapies that could significantly improve treatment outcomes. "We have developed a new way to engineer immune cells to fight cancer more safely and effectively. Think of it as reprogramming the body’s own soldiers (T cells) to recognize and attack cancer cells," says Cappabianca.
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