A living system, like any complex entity, is more than the sum of its parts. It can be as simple as a virus or as complex as an ecosystem. Researchers at WID aspire to gain an understanding of how such systems function, as well as how they adapt to and shape their environments over different time scales.

An interdisciplinary group of engineers, computer scientists, physicists, and evolutionary biologists take a multi-pronged approach to understanding living systems. We develop and combine experimental and computational methods to study diverse problems, ranging from interactions between organisms (e.g., between hosts and pathogens, and within diverse microbial communities) and interaction networks within organisms (e.g., regulatory and metabolic interactions). A common theme to complex biological systems research at WID is to view these systems through the lens of evolution.

WID alumnus awarded first AAAS Science & Technology Policy Fellowship in the U.S. Department of the Treasury

2024-11-14T22:45:03-06:00

WID and Saha Lab alumnus, and current postdoc at the Morgridge Institute for Research, Amritava Das anticipates that he will put his engineering and bioscience training to use exploring the sometimes knotty connections between science, national security, and finance.

WID alumnus awarded first AAAS Science & Technology Policy Fellowship in the U.S. Department of the Treasury2024-11-14T22:45:03-06:00

Molecular Puzzles in 3D: Understanding a Mechanism for Methylation

2025-01-27T14:53:02-06:00

A new publication from the Xuehua Zhong’s group at the Wisconsin Institute for Discovery and the genetics department at the University of Wisconsin–Madison clarifies an important epigenetic mechanism in plants that will help researchers better understand the epigenomes of both plants and animals.

Molecular Puzzles in 3D: Understanding a Mechanism for Methylation2025-01-27T14:53:02-06:00

Randolph Ashton and Collaborators Win WARF Innovation Award

2024-11-14T21:54:52-06:00

WID's Randolph Ashton, Gavin Knight, Benjamin Knudsen, and Nisha Iyer take top honors from the Wisconsin Alumni Research Foundation's Innovation Awards. Their work, Superior Neural Tissue Models for Disease Modeling, Drug Development and More, was selected from more than 400 innovation disclosures.

Randolph Ashton and Collaborators Win WARF Innovation Award2024-11-14T21:54:52-06:00

New Effective and Safe Antifungal Isolated from Sea Squirt Microbiome

2024-11-14T21:56:23-06:00

By combing the ocean for antimicrobials, scientists at the University of Wisconsin–Madison have discovered a new antifungal compound that efficiently targets multi-drug-resistant strains of deadly fungi without toxic side effects in mice. WID postdoc Marc Chevrette is part of the team that published the finding in Science.

New Effective and Safe Antifungal Isolated from Sea Squirt Microbiome2024-11-14T21:56:23-06:00

New Tool for Assessing Heart Muscle Cells Helps Unlock Their Potential

2024-11-14T21:59:49-06:00

A team of UW-Madison researchers led by Discovery Fellow Wendy Crone has created a powerful tool to help assess what experimental factors help to produce stem cell-generated cardiomyocytes that behave like adult heart cells.

New Tool for Assessing Heart Muscle Cells Helps Unlock Their Potential2024-11-14T21:59:49-06:00

Critical Communications Component Made on a Flexible Wooden Film

2024-11-14T22:00:14-06:00

WID's Shaoqin "Sarah" Gong is a collaborator on a paper published in Nature Communications in which UW engineers constructed a functional microwave amplifier circuit on a substrate of cellulose nanofibril paper, a wood product.

Critical Communications Component Made on a Flexible Wooden Film2024-11-14T22:00:14-06:00

Research on Viral Junk, Quicker Drug Testing Could Help Outflank Coronaviruses

2024-11-14T22:01:26-06:00

John Yin is working to find out whether "junk" particles produced by mouse viruses exist in human coronaviruses, and whether they may be the key to understanding how the viruses spread and interact with host cells.

Research on Viral Junk, Quicker Drug Testing Could Help Outflank Coronaviruses2024-11-14T22:01:26-06:00

Tiny Capsules Packed with Gene-Editing Tools Offer Alternative to Viral Delivery of Gene Therapy

2024-11-14T22:05:28-06:00

An interdisciplinary pair of WID researchers has developed a new nanocapsule delivery method for delivering the CRISPR-Cas9 gene editing tool. The new system could be used for many types of gene therapies.

Tiny Capsules Packed with Gene-Editing Tools Offer Alternative to Viral Delivery of Gene Therapy2024-11-14T22:05:28-06:00

Uncovering a Connection Between Regulators and Genes During Early Neurodevelopment

2025-01-27T14:18:51-06:00

WID researchers used a collaborative combination of computational and wet lab experimental techniques to find a connection between a transcription factor and a neurodevelopment gene.

Uncovering a Connection Between Regulators and Genes During Early Neurodevelopment2025-01-27T14:18:51-06:00

UW–Madison Researchers Earn Army Research Office Grant to Study Microbial Communication

2024-11-14T22:07:24-06:00

WID Director Jo Handelsman and biochemistry professor Ophelia Venturelli are part of a multi-university interdisciplinary team awarded a grant to study information transmission in microbial communities and how biological networks communicate.

UW–Madison Researchers Earn Army Research Office Grant to Study Microbial Communication2024-11-14T22:07:24-06:00

THOR Wrangles Complex Microbiomes into a Model for Improving Them

2025-01-27T14:36:51-06:00

A growing understanding of microbial communities and their influence on human health or crop productivity has led to the dream of changing these communities to produce benefits. New research at WID addresses this head-on.

THOR Wrangles Complex Microbiomes into a Model for Improving Them2025-01-27T14:36:51-06:00
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