Rachel Kruepke
Processing of stress, strain, and alignment data of stem cell derived cardiomyocytes
Tag: tissue engineering
The promise of tissue engineering stretches the limits of our imagination.
Biotechnology in general, and stem cell research in particular, has made great strides in spurring the growth (and re-growth) of specific human cell types. But cells alone cannot replace human tissue. Cells need scaffolds to serve as structural guides while growing into useful tissues or life-saving drug delivery systems.
Cell-scale scaffolds share similarities with building-scale scaffolds used in construction projects. Viable scaffolds allow for the mass transport of oxygen and nutrients. These scaffolds can direct the growth of cells migrating from nearby tissue or provide a foothold for new tissue growth. This directed growth could be used to replace destroyed nerves or heal fractured bones, damaged blood vessels, or parts of diseased organs.
Tissue engineering researchers at WID are laying the research foundation for these transformative scaffolding technologies. Ultimately, their work aims to heal damaged tissues with remarkable speed and minimal complications.
By working at the intersection of biotechnology and nanotechnology, tissue engineering researchers are building a library of scaffolding materials and cost-effective, mass-production methods that will work for a variety of cell types used in a wide range of in-body applications.
Randolph Ashton Named SCRMC Associate Director
WID’s Randolph Ashton, assistant professor of biomedical engineering, is the new associate director for UW–Madison’s Stem Cell and Regenerative Medicine Center.
Wisconsin State Journal: At UW-Madison, 500 Scientists Studying Stem Cells 20 Years After Discovery
The Wisconsin State Journal, as part of its feature highlighting stem cell research at UW 20 years after James Thomson’s discovery, highlights WID researchers Randolph Ashton and Kris Saha.
New Technology for Controlling Neural Tissue Manufacturing
A paper published in eLife this week by an interdisciplinary team at WID describes new methods for reproducibly manufacturing brain and spinal cord organoids with strict control over morphogenic and developmental processes.
Scientists Seek to Improve Quality Control for Genome Editing Therapies in the Eye
UW researchers led by WID’s Kris Saha join the National Institutes of Health’s Somatic Cell Genome Editing Consortium with a major collaborative award.
Micah Dombroe
Lab Manager
Genomic DNA sequencing and viral production. Facilitate various administrative functions.
Xianghui Xu
Research Scientist
Bioinspired macromolecular and supramolecular strategy for advanced biomaterials.
A Stent-Free Future for Common Cardiovascular Ailments
A team of researchers is developing a new approach for maintaining open blood vessels in the wake of surgeries such as angioplasties or bypasses.
WID Researchers Looking to the Future with UW2020 Awards
Investigators from WID are among the recipients of the latest round of UW2020 awards.
Undergraduate Nathan Wang Receives Goldwater Scholarship
The scholarship recognizes promising undergraduates who plan to pursue a PhD or MD/PhD followed by a research career in engineering, mathematics, or the natural sciences.
Britney Washington
Cryopreservation's effect on cell isolates and manufactured therapeutic phenotypes
Ben Knudsen
Mechanisms that promote the outgrowth of neural stem cells on micro patterned substrates.
New Hope for Stopping an Understudied Heart Disease in its Tracks
Biomedical engineering professor and Discovery Fellow Kristyn Masters and colleagues identified the early stages of a process that may eventually cause aortic stenosis, a severe narrowing of the aortic valve that reduces blood flow to the body and weakens the heart.
Shujie Yan
Visiting Scholar
Small-diameter vascular tissue engineering and biomedical scaffolds
Michael Murrell
Assistant Professor
Physics and Synthesis of Soft, Active and Biological Matter
Sean Palecek
Professor
Engineering platforms to regulate human pluripotent stem cell differentiation
Randolph Ashton Continues Research into Causes of Lou Gehrig’s Disease
In August 2017, Randolph Ashton received almost $800,000 from the National Institute of Neurological Disorders and Stroke, part of NIH, to continue a five-year research study of Lou Gehrig’s disease (amyotrophic lateral sclerosis, or ALS), after successfully completing its first phase.
Edwin Neumann
Reprogramming human breast cancer cells and watching epigenetic changes during cancer re-acquisition
UW-Madison to be Partner in Center for Cell Manufacturing Technologies
The National Science Foundation has awarded nearly $20 million to a consortium of universities to support a new engineering research center that will develop transformative tools and technologies for the consistent, scalable, and low-cost production of high-quality living therapeutic cells. Several WID investigators are collaborators on the project.
Louise Saraspe
In vitro modeling of CAR T cell cytotoxicity, activation, and exhaustion
Eduardo Enriquez
Multi-layered vascular scaffolds and use of nanoparticles to create wearable technology
Patricia Stan
Encouraging cardiomyocyte maturation through substrate mechanics.
George Schmidt
Injection molding of scaffolds for neural tissue engineering and paste extrusion of PTFE for small-diameter vascular grafts.