Tag: tissue engineering
The promise of tissue engineering stretches the limits of our imagination.
Biotechnology in general, and stem cell research in particular, has made great strides in spurring the growth (and re-growth) of specific human cell types. But cells alone cannot replace human tissue. Cells need scaffolds to serve as structural guides while growing into useful tissues or life-saving drug delivery systems.
Cell-scale scaffolds share similarities with building-scale scaffolds used in construction projects. Viable scaffolds allow for the mass transport of oxygen and nutrients. These scaffolds can direct the growth of cells migrating from nearby tissue or provide a foothold for new tissue growth. This directed growth could be used to replace destroyed nerves or heal fractured bones, damaged blood vessels, or parts of diseased organs.
Tissue engineering researchers at WID are laying the research foundation for these transformative scaffolding technologies. Ultimately, their work aims to heal damaged tissues with remarkable speed and minimal complications.
By working at the intersection of biotechnology and nanotechnology, tissue engineering researchers are building a library of scaffolding materials and cost-effective, mass-production methods that will work for a variety of cell types used in a wide range of in-body applications.
Josh Rawlins
Human cell engineering including CRISPR gene editing and epigenetic reprogramming
Shivani Saxena
Engineering cells and organism via genome editing and studying the delivery method for CRISPR/Cas9
Award-winning Grad Student Research Could Benefit Industry
Three members of Lih-Sheng (Tom) Turng’s research group at WID won top awards for their exceptional research papers in March.
Uncovering a Connection Between Regulators and Genes During Early Neurodevelopment
WID researchers used a collaborative combination of computational and wet lab experimental techniques to find a connection between a transcription factor and a neurodevelopment gene.
New Technique Enables Versatile 3D Control Over Stem Cell-Derived Organoids
WID researchers Randolph Ashton and Tom Turng partnered on a project to create hydrogel molds that will allow them to more precisely control the three-dimensional structures of organoids.
Revolutionary Engineered Blood Vessels Behave Like the Real Thing
WID’s Tom Turng envisions a future in which surgeons can order mass-produced artificial blood vessels that arrive ready to use in bypass surgeries.
Rachel Kruepke
Processing of stress, strain, and alignment data of stem cell derived cardiomyocytes
Randolph Ashton Named SCRMC Associate Director
WID’s Randolph Ashton, assistant professor of biomedical engineering, is the new associate director for UW–Madison’s Stem Cell and Regenerative Medicine Center.
Wisconsin State Journal: At UW-Madison, 500 Scientists Studying Stem Cells 20 Years After Discovery
The Wisconsin State Journal, as part of its feature highlighting stem cell research at UW 20 years after James Thomson’s discovery, highlights WID researchers Randolph Ashton and Kris Saha.
New Technology for Controlling Neural Tissue Manufacturing
A paper published in eLife this week by an interdisciplinary team at WID describes new methods for reproducibly manufacturing brain and spinal cord organoids with strict control over morphogenic and developmental processes.
Scientists Seek to Improve Quality Control for Genome Editing Therapies in the Eye
UW researchers led by WID’s Kris Saha join the National Institutes of Health’s Somatic Cell Genome Editing Consortium with a major collaborative award.
Micah Dombroe
Lab Manager
Genomic DNA sequencing and viral production. Facilitate various administrative functions.
A Stent-Free Future for Common Cardiovascular Ailments
A team of researchers is developing a new approach for maintaining open blood vessels in the wake of surgeries such as angioplasties or bypasses.
WID Researchers Looking to the Future with UW2020 Awards
Investigators from WID are among the recipients of the latest round of UW2020 awards.
Undergraduate Nathan Wang Receives Goldwater Scholarship
The scholarship recognizes promising undergraduates who plan to pursue a PhD or MD/PhD followed by a research career in engineering, mathematics, or the natural sciences.
Britney Washington
Cryopreservation's effect on cell isolates and manufactured therapeutic phenotypes
Ben Knudsen
Mechanisms that promote the outgrowth of neural stem cells on micro patterned substrates.
New Hope for Stopping an Understudied Heart Disease in its Tracks
Biomedical engineering professor and Discovery Fellow Kristyn Masters and colleagues identified the early stages of a process that may eventually cause aortic stenosis, a severe narrowing of the aortic valve that reduces blood flow to the body and weakens the heart.