New computation tools described in a recent study published in Nature Communications, may provide key insights that will aid researchers to construct a more precise view of what drives cellular identity. “We are trying to understand the causal mechanisms of how cells transition from one state, e.g., a pluripotent state to a more differentiated state, e.g. a skin or nerve cell and vice versa. We want to know how different normal cell types emerge and what might lead to cells becoming aberrant.” says Sushmita Roy. To gain such an understanding “we are developing computational tools that can integrate large-scale molecular profiles measured for each individual cell in a population of thousands of cells to define these GRNs” says Roy.

Research led by researchers at UW–Madison will leverage new ways of delivering drug therapies through nanotechnology with advanced genome CRISPR technology to innovate new treatments for two hereditary diseases that cause blindness.

Scientists worldwide are using authentic research experiences to engage college students in discovering new antibiotics. The Tiny Earth initiative, based at the Wisconsin Institute of Discovery, has already trained thousands of students in 30 countries. Congressionally Directed Community Project Funds will now provide $1 million to expand the program and reach even more students. This was part of the $1.7 trillion federal spending package that was signed into law by President Biden in December 2022.

Network of students, professors, researchers intertwine anti-racism curriculum, research to solve antibiotic resistance crisis

Researchers at the University of Wisconsin–Madison are developing the means to turn stem cells into a wide range of specific types of spinal cord neurons and cells in the hindbrain — the critical nexus between the spinal cord and the brain — paving the way for improved prevention and treatment of spinal cord disease.

A multilayered mural painted in bold colors now hangs in the atrium of the Discovery Building, depicting the many facets of STEM research and inspiring new generations to engage in science. Painted QR codes make the mural interactive, drawing the viewer into the stories of renowned and lesser known Wisconsin scientists whose contributions have shaped society.New interactive mural invites exploration and engagement with science

Tiny Earth will collaborate with Codon Learning and the National Institute on Scientific Teaching (NIST) to develop, evaluate, and disseminate a Scientific Teaching Course (STC) that integrates AJEDI (antiracist, just, equitable, diverse, inclusive) principles. The Course is designed as four modules and will be available via Codon Learning’s interactive digital platform beginning summer 2023. Modules will also be incorporated into Tiny Earth Partner Instructor (TEPI) training in summer 2023 and 2024.

UW–Madison researchers from Handelsman Lab have learned that a drastically scaled-down model of a microbial community makes it possible to observe some of the complex interactions.

Dr. Krishanu Saha along with Dr. Christian Capitini, is working to produce CAR T cells that could deliver results in solid tumors, using gene editing rather than a viral method to manufacture them.

In new research published today, UW–Madison WID researcher Shaoqin "Sarah" Gong, reported a new nanoparticle-based treatment for sepsis that delivers anti-inflammatory molecules and antibiotics.

While looking at a graph about fruit, it may seem intuitive to associate a bar of blue to blueberries and yellow to bananas, but are there connections between color and abstract concepts such as driving, comfort, efficiency, or reliability?   Understanding how people absorb meaning from visual features, and predicting the meaning they attribute to color in any context is filled with possibility.