A living system, like any complex entity, is more than the sum of its parts. It can be as simple as a virus or as complex as an ecosystem. Researchers at WID aspire to gain an understanding of how such systems function, as well as how they adapt to and shape their environments over different time scales.

An interdisciplinary group of engineers, computer scientists, physicists, and evolutionary biologists take a multi-pronged approach to understanding living systems. We develop and combine experimental and computational methods to study diverse problems, ranging from interactions between organisms (e.g., between hosts and pathogens, and within diverse microbial communities) and interaction networks within organisms (e.g., regulatory and metabolic interactions). A common theme to complex biological systems research at WID is to view these systems through the lens of evolution.

UW Carbone Scientists Present at Annual Cancer Research Conference

2024-11-14T22:11:58-06:00

One of the UW Carbone Cancer Center members presenting is WID's Peter Lewis. His work focuses on how genes are turned on and off during embryonic development, and how misregulation in those genes can lead to some childhood cancers.

UW Carbone Scientists Present at Annual Cancer Research Conference2024-11-14T22:11:58-06:00

Weaning Crops from Nitrogen Fertilizers: Examining Evolution’s Innovations

2024-11-14T22:15:51-06:00

WID researcher Sushmita Roy and collaborators at UW­–Madison and the University of Florida will use a $7 million grant from the U.S. Department of Energy to study how some plants partner with bacteria to create usable nitrogen and to transfer this ability to the bioenergy crop poplar.

Weaning Crops from Nitrogen Fertilizers: Examining Evolution’s Innovations2024-11-14T22:15:51-06:00

Connecting the Dots: a New Method to Understand Cell Type Transitions

2025-01-27T14:49:18-06:00

Wisconsin Institute for Discovery (WID) researchers Rupa Sridharan and Sushmita Roy are combining their expertise in regenerative biology and computational biology to better understand how cells transition from one type to another through gene regulation.

Connecting the Dots: a New Method to Understand Cell Type Transitions2025-01-27T14:49:18-06:00

You may also like … Algorithms that improve drug discovery

2024-11-14T22:18:24-06:00

WID researchers Stephen Wright and Robert Nowak are part of a UW2020: WARF Discovery Initiative project to create machine learning tools that dramatically reduce the time and cost associated with screening compounds for therapeutic relevance.

You may also like … Algorithms that improve drug discovery2024-11-14T22:18:24-06:00

Phenotypic variability and community interactions of germinating Streptomyces spores

2025-01-27T14:21:01-06:00

Systems Biology researcher Kalin Vetsigian and graduate student Ye Xu recently published findings in Nature's Scientific Reports about the stochasticity of growth within Streptomycetes spore communities.

Phenotypic variability and community interactions of germinating Streptomyces spores2025-01-27T14:21:01-06:00

Understanding the Immune System with Machine Learning

2025-01-27T14:12:32-06:00

Systems Biology researchers Deborah Chasman and Sushmita Roy are using machine learning to identify virus and pathogenicity-specific regulatory networks which may guide the design of effective therapeutics for infectious diseases. The work is described in a recent paper in PLOS Computational Biology.

Understanding the Immune System with Machine Learning2025-01-27T14:12:32-06:00

John Yin: “Arrow In, Arrow Out: Rumination on the Origins of Life and Nurturing Research Collaborations”

2024-11-14T22:28:15-06:00

John Yin spoke at the Discovery Seminar Series in January, 2016, offering his perspective on the origins of life, dynamic stability, and developing collaborations.

John Yin: “Arrow In, Arrow Out: Rumination on the Origins of Life and Nurturing Research Collaborations”2024-11-14T22:28:15-06:00

Systems Biology Researchers Study Co-infections of Viable and Defective Viruses

2024-11-14T22:29:05-06:00

The paper, titled 'High-throughput single-cell kinetics of virus infections in the presence of defective interfering particles', was published in the current issue of the Journal of Virology.

Systems Biology Researchers Study Co-infections of Viable and Defective Viruses2024-11-14T22:29:05-06:00
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