Stuart Fass
Genetic basis for Polyethylene degradation in Galleria mellonella gut flora
Tag: complex biological systems
A living system, like any complex entity, is more than the sum of its parts. It can be as simple as a virus or as complex as an ecosystem. Researchers at WID aspire to gain an understanding of how such systems function, as well as how they adapt to and shape their environments over different time scales.
An interdisciplinary group of engineers, computer scientists, physicists, and evolutionary biologists take a multi-pronged approach to understanding living systems. We develop and combine experimental and computational methods to study diverse problems, ranging from interactions between organisms (e.g., between hosts and pathogens, and within diverse microbial communities) and interaction networks within organisms (e.g., regulatory and metabolic interactions). A common theme to complex biological systems research at WID is to view these systems through the lens of evolution.
UW–Madison Researchers Earn Army Research Office Grant to Study Microbial Communication
WID Director Jo Handelsman and biochemistry professor Ophelia Venturelli are part of a multi-university interdisciplinary team awarded a grant to study information transmission in microbial communities and how biological networks communicate.
Seminar on Astrobiology Aims to Inspire a Look into the Bounds of Life
A new group centered at WID hopes to coordinate the dozens of labs that are addressing some aspect of astrobiology and inspire others to join the work. A public lecture series this spring is part of the effort.
THOR Wrangles Complex Microbiomes into a Model for Improving Them
A growing understanding of microbial communities and their influence on human health or crop productivity has led to the dream of changing these communities to produce benefits. New research at WID addresses this head-on.
Tessa Doersch
Developing Stem Cell-Derived Dorsal Horn Interneurons for Regeneration of Somatosensory Circuits
Logan Wright
A proteomics approach to gut microbial interactions that drive epigenetic changes in human metabolism
Noah Nicol
Dorsal horn interneuron generation from ESC and spinal integration of regionalized transplants.
WID Seeks Machine Learning and “Fluxomics” Hires
WID seeks to add to its roster of excellent faculty with two new hires in emerging cutting-edge fields.
WID Hubs Launch at Illuminating Connections Event
WID’s new hubs—Data Science, Multi-Omics, and Illuminating Discovery—represent a new path forward for collaborative research projects and fields.
Erika Da-Inn Lee
Developing computational tools to learn the principles of genome organization
Could Yesterday’s Earth Contain Clues for Making Tomorrow’s Medicines?
WID’s John Yin and colleagues have described initial steps toward achieving chemistries that encode information in a variety of conditions that might mimic the environment of prehistoric Earth.
Jacky Tian
Development of motor neurons derived from human stem cells via sectioning, staining, and microscopy
Molly Carroll
Application of computational models to predict cancer prognostics from proteomics and secretomics
Fast Evolution Unlocks Forbidden Communities
Writing in Nature Ecology & Evolution, WID’s Seyfullah Kotil and Kalin Vetsigian uncover an assembly mechanism that can lead to the spontaneous formation of microbial communities.
Micah Dombroe
Lab Manager
Genomic DNA sequencing and viral production. Facilitate various administrative functions.
The Big Dig: Tiny Earth Studentsources Antibiotic Discovery
From On Wisconsin Magazine: UW-Madison students are joining the hunt for new antibiotics in their introductory biology coursework and becoming part of the Tiny Earth network, based at the Wisconsin Institute for Discovery.
Scientists Discovered How PCK1 Gene Is Involved In Diabetes and Metastasis in Some Types of Cancer
An international team of researchers including WID scientists has discovered new mechanisms to regulate the activity of a gene essential in metabolism, with implications for pathologies related to alterations in glucose levels in the body, such as diabetes or metastasis in some types of cancer.