Josh Rawlins
Human cell engineering including CRISPR gene editing and epigenetic reprogramming
Tag: epigenetics
Epigenetics researchers at WID examine how the epigenome — the layer of chemical information that sits on top of the genome — switches genes ‘on’ or ‘off’ and is controlled by outside factors such as lifestyle and diet. Research in this area focuses on the molecular, chemical, and physical components underlying epigenetic mechanisms and utilizes genomic, proteomic, and biochemical methods to reveal novel epigenetic information and mechanisms. We are investigating how extrinsic factors (diet, small-molecules, metabolism and environmental factors) influence the epigenome and control cellular decision and are developing new technologies to uncover and interrogate the epigenetic code written in chemical tags.
As part of WID’s Multi-Omics Hub, the Epigenetics Initiative reaches out to foster interdisciplinary collaborations with basic and translational research in epigenetics and chromatin function.
Ryan Herringa
Associate Professor
Neurodevelopmental mechanisms of stress and mental illness in youth
Amulya Suresh
CRISPR-Cas9 Strategy to Generate DOT1L-Deficient Embryonic Stem Cells to Study Pluripotency
Logan Wright
A proteomics approach to gut microbial interactions that drive epigenetic changes in human metabolism
Robert Miner
Lab Technician
Developing a high-throughput assay to identify inhibitors of histone-binding domains of UHRF1
WID Seeks Machine Learning and “Fluxomics” Hires
WID seeks to add to its roster of excellent faculty with two new hires in emerging cutting-edge fields.
WID Hubs Launch at Illuminating Connections Event
WID’s new hubs—Data Science, Multi-Omics, and Illuminating Discovery—represent a new path forward for collaborative research projects and fields.
Tour WID’s New ‘Hubs’ Designed to Spur Campus Collaborations Dec. 12
The Wisconsin Institute for Discovery will launch a suite of hubs designed to bring together researchers from across campus and provide access to specialized tools and resources.
Erika Da-Inn Lee
Developing computational tools to learn the principles of genome organization
Jacky Tian
Development of motor neurons derived from human stem cells via sectioning, staining, and microscopy
Micah Dombroe
Lab Manager
Genomic DNA sequencing and viral production. Facilitate various administrative functions.
Scientists Discovered How PCK1 Gene Is Involved In Diabetes and Metastasis in Some Types of Cancer
An international team of researchers including WID scientists has discovered new mechanisms to regulate the activity of a gene essential in metabolism, with implications for pathologies related to alterations in glucose levels in the body, such as diabetes or metastasis in some types of cancer.
Combining On and Off Switches, One Protein Can Control Flowering in Plants
With Wisconsin’s short growing seasons, reducing a plant’s life cycle and completing the season earlier “could be very important for many crops.”
How Mutations in Cell DNA Can Lead to Cancer
Peter Lewis and his research group at WID study how mutations in DNA-organizing histone proteins lead to cancer development.
WID Researchers Looking to the Future with UW2020 Awards
Investigators from WID are among the recipients of the latest round of UW2020 awards.
UW Carbone Scientists Present at Annual Cancer Research Conference
One of the UW Carbone Cancer Center members presenting is WID’s Peter Lewis. His work focuses on how genes are turned on and off during embryonic development, and how misregulation in those genes can lead to some childhood cancers.
Stefan Pietrzak
Transcriptional and epigenetic mechanisms regulating cellular differentiation and reprogramming