Cindy Liu
CRISPR-mediated knock-ins of Polycomb-associated DNA elements in Arabidopsis thaliana
Tag: gene editing
The advent of the CRISPR-CAS9 technique gives researchers the ability to make precise changes to the DNA of, theoretically, any living organism that has DNA. That precision is particularly meaningful for treatment of diseases caused by well-known faults in genes — otherwise incurable diseases such as sickle cell anemia, the fatal lung disorder cystic fibrosis, and the blindness-causing Leber congenital amaurosis. CRISPR-Cas9 could be a way to prevent or reverse those disorders.
Mackenzie Beam
Mechanism that links neurodegenerative diseases to lysosomal and endosomal dysfunction.
Jacobus (Jack) Burger
Developing biomedical nanomaterials for drug delivery applications
WID alumnus awarded first AAAS Science & Technology Policy Fellowship in the U.S. Department of the Treasury
WID and Saha Lab alumnus, and current postdoc at the Morgridge Institute for Research, Amritava Das anticipates that he will put his engineering and bioscience training to use exploring the sometimes knotty connections between science, national security, and finance.
Harshini Cormaty
Epigenetic mechanisms that control Primordial Germ Cell differentiation in mice
Fixing Genetic Mistakes to Restore Vision
Shaoqin “Sarah” Gong collaborates on a new approach to target genetic mutations and develop a new therapy for restoring vision in children and adults.
Nan (Yifang) Jiang
Functions of human coronaviruses defective genomes on the range and severity of diseases.
Researchers Design New Strategy for Gene Therapy Development
A promising platform developed by the Saha Lab at WID advances the CRISPR genome editing field and could lead to effective treatments for many diseases.
Dan Cappabianca
Novel CAR T Cell therapy development in translational and bench top settings
UW Researchers Devise Approach to Treat Rare, Incurable Form of Blindness
WID’s Kris Saha was among UW–Madison researchers who have published a proof-of-concept method to correct an inherited form of macular degeneration that causes blindness, and that is currently untreatable.
WPR: An Exciting Development, CRISPR Lets UW-Madison Researchers Edit Genes
WID’s Kris Saha spoke to Wisconsin Public Radio to answer questions about gene editing technology CRISPR in response to a question received by WHYsconsin.
Human Nature Screening
The the MS Biotechnology program at UW and the Wisconsin Institute for Discovery are partnering to screen the documentary film “Human Nature”, an exploration of gene editing and its implications both biological and ethical.
Xiaoya Zhang
Epigenetic control of cell identity in development and somatic cell reprogramming.
Should We Alter the Human Genome? Let Democracy Decide
WID’s Krishanu Saha and colleagues J. Benjamin Hurlbut and Sheila Jasanoff write in Scientific American about germ line editing and the need for more scientific and moral clarity.
Tiny Capsules Packed with Gene-Editing Tools Offer Alternative to Viral Delivery of Gene Therapy
An interdisciplinary pair of WID researchers has developed a new nanocapsule delivery method for delivering the CRISPR-Cas9 gene editing tool. The new system could be used for many types of gene therapies.