Tag: gene editing
The advent of the CRISPR-CAS9 technique gives researchers the ability to make precise changes to the DNA of, theoretically, any living organism that has DNA. That precision is particularly meaningful for treatment of diseases caused by well-known faults in genes — otherwise incurable diseases such as sickle cell anemia, the fatal lung disorder cystic fibrosis, and the blindness-causing Leber congenital amaurosis. CRISPR-Cas9 could be a way to prevent or reverse those disorders.
Xiaoya Zhang
Epigenetic control of cell identity in development and somatic cell reprogramming.
Should We Alter the Human Genome? Let Democracy Decide
WID’s Krishanu Saha and colleagues J. Benjamin Hurlbut and Sheila Jasanoff write in Scientific American about germ line editing and the need for more scientific and moral clarity.
Tiny Capsules Packed with Gene-Editing Tools Offer Alternative to Viral Delivery of Gene Therapy
An interdisciplinary pair of WID researchers has developed a new nanocapsule delivery method for delivering the CRISPR-Cas9 gene editing tool. The new system could be used for many types of gene therapies.
Josh Rawlins
Human cell engineering including CRISPR gene editing and epigenetic reprogramming
Shivani Saxena
Engineering cells and organism via genome editing and studying the delivery method for CRISPR/Cas9
Amulya Suresh
CRISPR-Cas9 Strategy to Generate DOT1L-Deficient Embryonic Stem Cells to Study Pluripotency
Randolph Ashton Named SCRMC Associate Director
WID’s Randolph Ashton, assistant professor of biomedical engineering, is the new associate director for UW–Madison’s Stem Cell and Regenerative Medicine Center.
Wisconsin State Journal: At UW-Madison, 500 Scientists Studying Stem Cells 20 Years After Discovery
The Wisconsin State Journal, as part of its feature highlighting stem cell research at UW 20 years after James Thomson’s discovery, highlights WID researchers Randolph Ashton and Kris Saha.
UW–Madison Researchers Developing Methods to Edit Genes in Brain Cells
A second WID-led team joins NIH’s Somatic Cell Genome Editing Consortium with a grant to study new methods of delivering the CRISPR/Cas9 system to the brain.
Scientists Seek to Improve Quality Control for Genome Editing Therapies in the Eye
UW researchers led by WID’s Kris Saha join the National Institutes of Health’s Somatic Cell Genome Editing Consortium with a major collaborative award.
Jacky Tian
Development of motor neurons derived from human stem cells via sectioning, staining, and microscopy
Micah Dombroe
Lab Manager
Genomic DNA sequencing and viral production. Facilitate various administrative functions.
WID Researchers Looking to the Future with UW2020 Awards
Investigators from WID are among the recipients of the latest round of UW2020 awards.
All-in-One Repair Kit Makes CRISPR Gene Editing More Precise
Error rates as high as 50 percent are a problem when the goal is to correct typos in the DNA that cause genetic disease. Now, a team of researchers led by WID’s Kris Saha has made the fix less mistake-prone.
Sean Palecek
Professor
Engineering platforms to regulate human pluripotent stem cell differentiation
UW-Madison to be Partner in Center for Cell Manufacturing Technologies
The National Science Foundation has awarded nearly $20 million to a consortium of universities to support a new engineering research center that will develop transformative tools and technologies for the consistent, scalable, and low-cost production of high-quality living therapeutic cells. Several WID investigators are collaborators on the project.
Louise Saraspe
In vitro modeling of CAR T cell cytotoxicity, activation, and exhaustion