WID Researchers Looking to the Future with UW2020 Awards
Investigators from WID are among the recipients of the latest round of UW2020 awards.
Tag: gene editing
The advent of the CRISPR-CAS9 technique gives researchers the ability to make precise changes to the DNA of, theoretically, any living organism that has DNA. That precision is particularly meaningful for treatment of diseases caused by well-known faults in genes — otherwise incurable diseases such as sickle cell anemia, the fatal lung disorder cystic fibrosis, and the blindness-causing Leber congenital amaurosis. CRISPR-Cas9 could be a way to prevent or reverse those disorders.
Rachel Grosser
Methodology research related to CAR T cell gene therapy for cancer patients.
All-in-One Repair Kit Makes CRISPR Gene Editing More Precise
Error rates as high as 50 percent are a problem when the goal is to correct typos in the DNA that cause genetic disease. Now, a team of researchers led by WID’s Kris Saha has made the fix less mistake-prone.
Sean Palecek
Professor
Engineering platforms to regulate human pluripotent stem cell differentiation
Edwin Neumann
Reprogramming human breast cancer cells and watching epigenetic changes during cancer re-acquisition
UW-Madison to be Partner in Center for Cell Manufacturing Technologies
The National Science Foundation has awarded nearly $20 million to a consortium of universities to support a new engineering research center that will develop transformative tools and technologies for the consistent, scalable, and low-cost production of high-quality living therapeutic cells. Several WID investigators are collaborators on the project.
Louise Saraspe
In vitro modeling of CAR T cell cytotoxicity, activation, and exhaustion
Evan Cory
Disease modeling using CRISPR/Cas9 gene editing and directed differentiation of human stem cells
Kevin Mayer
How does plant chromatin regulate gene expression in response to environmental stress?
Peter Lewis
Assistant Professor
Investigating chromatin dynamics in animal development and cancer.
Jared Carlson-Stevermer
Development of gene editing technologies in human pluripotent stem cells
Nicole Piscopo
High-Content Analysis of Heterogeneity in Manufacturing of Chimeric Antigen Receptor (CAR) T Cells.
Shaoqin (Sarah) Gong
Kellett Mid-Career Award 2018-2023
Vilas Distinguished Achievement Professor
Creating nanomedicines and nanomaterials for human health and sustainable energy applications.
Krishanu Saha
Assistant Professor
Human cell engineering including CRISPR gene editing and epigenetic reprogramming; science & society