The advent of the CRISPR-CAS9 technique gives researchers the ability to make precise changes to the DNA of, theoretically, any living organism that has DNA. That precision is particularly meaningful for treatment of diseases caused by well-known faults in genes — otherwise incurable diseases such as sickle cell anemia, the fatal lung disorder cystic fibrosis, and the blindness-causing Leber congenital amaurosis. CRISPR-Cas9 could be a way to prevent or reverse those disorders.
Katherine P. Meuller, PhD and Nicole J. Piscopo win with “Production and characterization of virus-free, CRISPR-CAR T cells capable of inducing solid tumor regression”
WID and Saha Lab alumnus, and current postdoc at the Morgridge Institute for Research, Amritava Das anticipates that he will put his engineering and bioscience training to use exploring the sometimes knotty connections between science, national security, and finance.
Shaoqin “Sarah” Gong collaborates on a new approach to target genetic mutations and develop a new therapy for restoring vision in children and adults.
A promising platform developed by the Saha Lab at WID advances the CRISPR genome editing field and could lead to effective treatments for many diseases.
WID’s Kris Saha was among UW–Madison researchers who have published a proof-of-concept method to correct an inherited form of macular degeneration that causes blindness, and that is currently untreatable.
WID’s Kris Saha spoke to Wisconsin Public Radio to answer questions about gene editing technology CRISPR in response to a question received by WHYsconsin.
WID’s Krishanu Saha and colleagues J. Benjamin Hurlbut and Sheila Jasanoff write in Scientific American about germ line editing and the need for more scientific and moral clarity.
An interdisciplinary pair of WID researchers has developed a new nanocapsule delivery method for delivering the CRISPR-Cas9 gene editing tool. The new system could be used for many types of gene therapies.
WID’s Randolph Ashton, assistant professor of biomedical engineering, is the new associate director for UW–Madison’s Stem Cell and Regenerative Medicine Center.
The Wisconsin State Journal, as part of its feature highlighting stem cell research at UW 20 years after James Thomson’s discovery, highlights WID researchers Randolph Ashton and Kris Saha.
A second WID-led team joins NIH’s Somatic Cell Genome Editing Consortium with a grant to study new methods of delivering the CRISPR/Cas9 system to the brain.
UW researchers led by WID’s Kris Saha join the National Institutes of Health’s Somatic Cell Genome Editing Consortium with a major collaborative award.
Investigators from WID are among the recipients of the latest round of UW2020 awards.
Error rates as high as 50 percent are a problem when the goal is to correct typos in the DNA that cause genetic disease. Now, a team of researchers led by WID’s Kris Saha has made the fix less mistake-prone.
The National Science Foundation has awarded nearly $20 million to a consortium of universities to support a new engineering research center that will develop transformative tools and technologies for the consistent, scalable, and low-cost production of high-quality living therapeutic cells. Several WID investigators are collaborators on the project.
Kris Saha illuminates the inner workings of gene editing.
Kris Saha with colleagues David Beebe and Christian Capitini aim to develop improved methods for making CAR T-Cells with a two-year grant from the NSF.
Tools for Discovery is a monthly profile series that inspects the computer programs, gadgets and methods behind WID’s ideas and discoveries.
New genome editing technique can target single letters of DNA sequence.
Kris Saha and colleagues from the BIONATES Theme detail a new approach that can refine gene editing in this month’s issue of Stem Cell Reports.
Kris Saha, Assistant Professor in the BIONATES theme, is featured in a Genetic Engineering & Biotechnology News article for his work with High Content Analysis.
Assistant Professor and BIONATES theme PI Krishanu Saha along with J. Benjamin Hurlbut, Assistant Professor, Human Dimensions at Arizona State University and Sheila Jasanoff, Professor of Science and Technology at Harvard University co-authored a recent article for Issues in Science and Technology making the case for how far scientists should go in researching and applying CRISPR to editing the human germline.
Krishanu Saha, principal investigator in BIONATES, along with Sheila Jasanoff of the Harvard Kennedy School and J. Benjamin Hurlbut from Arizona State University weigh in on moratoriums for germline gene engineering for this Guardian op-ed piece.
Systems Biology scientist Sushmita Roy finds and predicts trends in biological networks. Her toolkit includes computer science programs, blogs and other bright minds in the Discovery Building.
