Krishanu Saha and Melissa Skala have devised an innovative method for reprogramming cells that leverages micropatterning, label-free imaging and machine learning to enable real-time, noninvasive monitoring of reprogramming. This method can be used to develop cutting-edge personalized therapies and disease models.
While looking at a graph about fruit, it may seem intuitive to associate a bar of blue to blueberries and yellow to bananas, but are there connections between color and abstract concepts such as driving, comfort, efficiency, or reliability? Understanding how people absorb meaning from visual features, and predicting the meaning they attribute to color in any context is filled with possibility.
Claudia Solís-Lemus’ has been awarded a coveted five-year research grant from the National Science Foundation’s Faculty Early Career Development (CAREER) Award. Solís-Lemus’ NSF grant will support her research, which combines statistical theory and biology to help understand how the biodiversity that we see on Earth evolved from single-cell organisms.
Through a series of lab studies between 2010 and 2017, Karen Schloss, PhD and her collaborator, Stephen Palmer PhD, a researcher at UC Berkeley, set out to find out why we like certain colors more than others.
They hypothesized the Ecological Valence Theory (EVT), which they describe in their 2017 paper as the theory that “…people like/dislike a given color to the degree that they like/dislike all of the objects and entities that they associate with that color.”
In a new study, the John Denu lab has learned that the fatty acids butyrate and propionate also activate p300, a crucial human enzyme that promotes the unspooling of DNA. This unwound DNA allows more genes to become active and expressed, which ultimately affects human health.
While studying the three-member model microbial community, nicknamed The Hitchhikers of the Rhizosphere (THOR), researchers from professor of plant pathology and director of the Wisconsin Institute for Discovery Jo Handelsman and professor of biomedical engineering and Discovery Fellow David Beebe’s labs noticed cells moving in unexpected, unique ways under the microscope.
Researchers from the Neuroimaging Center at NYU Abu Dhabi (NYUAD) and Dr. Karen Schloss from Wisconsin Institute for the Discovery at University Wisconsin-Madison have developed the UW Virtual Brain Project, producing unique, interactive, 3D narrated diagrams to help students learn about the structure and function of perceptual systems in the human brain.
Claudia Solís-Lemus reveals a clearer picture of the evolutionary interconnectedness of organisms by modeling data, both big and small
A new publication from the Xuehua Zhong’s group at the Wisconsin Institute for Discovery and the genetics department at the University of Wisconsin–Madison clarifies an important epigenetic mechanism in plants that will help researchers better understand the epigenomes of both plants and animals.
WID’s Sarah Gong is part of a team that developed a micro-molded scaffolding photoreceptor “patch” to be implanted under damaged or diseased retinas, the next step in restoring sight.
A new application of nanomedicine from Shaoqin Gong’s lab, published in Advanced Materials, may be a potent tool in the fight against antimicrobial-resistant infections.
Innovations from associate professor of biostatistics and medical informatics Sushmita Roy can help scientists to better understand evolutionary processes, especially across multiple species and complex gene regulatory networks.
Shaoqin “Sarah” Gong collaborates on a new approach to target genetic mutations and develop a new therapy for restoring vision in children and adults.
Using a microscopic retinal patch, researchers at the University of Wisconsin‒Madison will develop and test a new way to treat United States military personnel blinded in combat with help from engineers including WID’s Sarah Gong.
A promising platform developed by the Saha Lab at WID advances the CRISPR genome editing field and could lead to effective treatments for many diseases.
By combing the ocean for antimicrobials, scientists at the University of Wisconsin–Madison have discovered a new antifungal compound that efficiently targets multi-drug-resistant strains of deadly fungi without toxic side effects in mice. WID postdoc Marc Chevrette is part of the team that published the finding in Science.
WID’s Kris Saha was among UW–Madison researchers who have published a proof-of-concept method to correct an inherited form of macular degeneration that causes blindness, and that is currently untreatable.
A team of UW-Madison researchers led by Discovery Fellow Wendy Crone has created a powerful tool to help assess what experimental factors help to produce stem cell-generated cardiomyocytes that behave like adult heart cells.
University of Wisconsin-Madison engineers led by WID’s Shaoqin “Sarah” Gong have developed a nanoparticle that could safely carry a variety of payloads into targeted cells, giving researchers a versatile, nonviral option for delivering drugs, gene-editing tools, DNA and more.
John Yin is working to find out whether “junk” particles produced by mouse viruses exist in human coronaviruses, and whether they may be the key to understanding how the viruses spread and interact with host cells.
WID’s John Yin, who uses experimental and computational methods to understand how viruses spread, is working on several projects that could have a direct bearing on COVID-19.
Discovery Fellow Jim Luedtke, a professor of industrial and systems engineering at the University of Wisconsin-Madison, specializes in stochastic and integer optimization, a natural fit for power systems.
WID researchers have developed a computational tool that can accurately predict the three-dimensional interactions between regions of human chromosomes.
Discovery Fellow David Baum leads a team that has cultivated lifelike chemical reactions while pioneering a new strategy for studying the origin of life.
Xuehua Zhong’s close study of an ordinary plant’s cellular mechanisms could lead to big advances in agriculture and medicine. Zhong is featured in Grow magazine.