Featured WID Projects

Project
Started
A CRISPR/Cas9 Based Therapeutic Strategy for Alzheimer’s DiseaseSubhojit Roy (PI)
Shaoqin (Sarah) Gong (co-PI)
Krishanu Saha (co-PI)
Wisconsin Alumni Research FoundationDepartment of Anatomic Pathology2017
A Novel Direction in Mixed Integer Polynomial Optimization: Structural Properties, Polyhedral Approximations, and Global Optimization AlgorithmsAlberto Del Pia (PI)
Silvia Di Gregorio
National Science FoundationData Science Hub2017
A Virtual Tour Through Mount Horeb Area HistoryKevin Ponto (PI)
Ross Tredinnick (PI)
Raymond and Margaret Vicker Charitable Trust2017
Alfred Toepfer Faculty Fellow AwardXuehua Zhong (PI)University of Wisconsin Foundation2016
An Endothelium-Protective Stent-Free Strategy for Mitigation of Intimal Hyperplasia After Vascular SurgeryShaoqin (Sarah) Gong (PI)
Craig Kent (PI)
Lian-Wang Guo (PI)
DHHS
National Institutes of Health
Department of Biomedical Engineering2018
Analyzing the Impact of Virtual Reality and 3D Capture Technology on Crime Scene InvestigationKevin Ponto (PI)
Ross Tredinnick
Simon Smith
Department of Justice2017
Assembly of Novel Gene Editing Particles to Understand Genome Surgery in Patient-Derived CellsKrishanu Saha (PI)
Amr Abdeen
DHHS
National Institutes of Health
2016
BIGDATA: Human and Machine Co-ProcessingRobert Nowak (PI)
Stephen Wright (Co-PI)
Michael O’Neill
Michael O’Neill
National Science Foundation2014
Bioengineering Micro-Patterned Scaffolds for Human Pluripotent Stem Cell-Based Photoreceptor Replacement TherapiesDavid Gamm (PI)
Zhenqiang Jack Ma (co-PI)
Shaoqin (Sarah) Gong (co-PI)
Foundation For Fighting BlindnessWasiman Center2016
Brain Comp Infra: Workshop: Research Methods and Infrastructure for Scalable Computing in NeuroscienceLauren Michael (PI)National Science FoundationData Science Hub2016
CAREER: Comparative Network Biology to Study the Evolution of Regulatory NetworksSushmita Roy (PI)
Alireza Fotuhi Siahpirani
Sara Knaack
Christina Koch
National Science FoundationDepartment of Biostatistics and Medical Informatics2014
CAREER: Engineering Human CNS Morphogenesis Ex Vivo: Spinal CordRandolph Ashton (PI)
Carlos Marti-Figueroa
National Science FoundationDepartment of Biomedical Engineering2017
CAREER: Modeling Made EasyLaurence Loewe (PI)National Science Foundation2012
CAREER: Molecular Dissection of  Arabidopsis  DNA Methylation MechanismXuehua Zhong (PI)
Xiangsong Chen
Jianjun Jiang
National Science FoundationLaboratory of Genetics2015
CAREER: Towards Synthetic Biology in Human Stem CellsKrishanu Saha (PI),National Science FoundationDepartment of Biomedical Engineering2014
Chromatin Remodeling and Signaling PathwaysRupa Sridharan (PI)
Zafirah Zaidan
DHHS
National Institutes of Health
2015
Clustering of Time Series for Usage-Based InsuranceAmerican Family InsuranceData Science Hub2018
CNF-Based Large-Area High-Performance Flexible ElectronicsZhenqiang Jack Ma (PI)
Shaoqin (Sarah) Gong (co-PI)
US Endowment for Forestry and CommunitiesDepartment of Biomedical Engineering2017
Computational approaches for comparative regulatory genomics to decipher long range gene regulationSushmita Roy (PI)DHHS
National Institutes of Health
Department of Biostatistics and Medical Informatics2018
Computational Inference of Regulatory Network Dynamics on Cell LineagesSushmita Roy (PI)
Rupa Sridharan (Co-PI)
Alireza Fotuhi Siahpirani
Sara Knaack
Shilu Zhang
DHHS
National Institutes of Health
2016
CRII: CIF: Universal Analysis of Optimization AlgorithmsLaurent Lessard (PI)
Saman Cyrus
Akhil Sundararajan
National Science FoundationData Science Hub
Department of Electrical and Computer Engineering
2017
Design of a Database for Graduate Education in Data AnalyticsJo Handelsman (PI)
Josh Pultorak
Alfred P. Sloan FoundationMulti-Omics Hub2017
Development and Preclinical Testing of Multifunctional Nanoparticles for Optimizing the In Situ Tumor Vaccine Effect of Radiation TherapyZachary Morris (PI)
Shaoqin (Sarah) Gong (co-PI)
Wisconsin Alumni Research FoundationDepartment of Biomedical Engineering
Department of Oncology
2019
Development of Unimolecular Nanoparticle-Mediated Periadventitial Drug Delivery System for Sustained and Targeted Inhibition of Intimal Hyperplasia Following Open Vascular ReconstructionShaoqin (Sarah) Gong (PI)
Craig Kent (PI)
Lian-Wang Guo (PI)
Yuyuan Wang
DHHS
National Institutes of Health
Department of Surgery2016
Dissecting Molecular Mechanisms of Astrocyte-Neuron Interaction in Rett Syndrome Using Arrays of Gene-Edited, Patient-Derived CellsKrishanu Saha (PI)
Kaivalya Molugu
Alireza Aghayee
Brain and Behavior Research Foundation2017
EAGER: A Microscale Testbed to Assay and Manufacture CAR T-Cell ImmunotherapiesKrishanu Saha (PI)
Katie Mueller
Nicole Piscopo
National Science Foundation2016
Elucidating Mechanisms of Chromatin Dysregulation by Oncohistones in Pediatric CancersPeter Lewis (PI)Kimmel FoundationMulti-Omics Hub2015
Enabling Nanoplatforms for Targeted in vivo Delivery of CRISPR/Cas9 Ribonucleoproteins in the BrainShaoqin (Sarah) Gong (PI)
Marina Emborg (co-PI)
Jon Levine (co-PI)
Subhojit Roy (co-PI)
Krishanu Saha (co-PI)
DHHS
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Department of Biomedical Engineering
Department of Pathology and Laboratory Medicine
Medical Physics
Primate Center
2018
EPCN: Robust Control Architectures for Decentralized Uncertain SystemsLaurent Lessard (PI)National Science FoundationData Science Hub2017
Epigenetic Regulation and Agricultural ProductivityXuehua Zhong (PI)Hatch Act Formula FundLaboratory of Genetics2016
Ethnography of Home SecurityRobert Nowak (PI)American Family InsuranceData Science Hub2016
Evolution of Virus-Host InteractionsJohn Yin (PI)
Paul Turner (Yale University) (co-PI)
Huicheng Shi
DHHS
National Institutes of Health
Department of Chemical and Biological Engineering2010
Explanation-Based Active LearningRobert Nowak (PI)American Family InsuranceData Science Hub
Department of Electrical and Computer Engineering
2018
Exploring the Universe from AntarcticaKevin Ponto (PI)
Ross Tredinnick
National Science FoundationData Science Hub2016
High-Throughput Modeling of ALS Using iPSC-Derived Neural Tube MicroarraysRandolph Ashton (PI)
David Beebe (co-PI)
Gavin Knight
Carlos Marti-Figueroa
DHHS
National Institutes of Health
2014
Human Models for Analysis of Pathways CenterRandolph Ashton (co-PI)
Sushmita Roy (co-PI)
Krishanu Saha (Co-PI)
Environmental Protection AgencyDepartment of Orthopedics and Rehabilitation2014
Inference for Autoregressive Point Processes
Garvesh Raskutti (co-PI)
National Geospatial-Intelligence AgencyData Science Hub2017
Inference for High-Dimensional Self-Exciting Point Processes
Garvesh Raskutti (co-PI)
Department of Defense - ArmyData Science Hub2017
Informing Great Lakes Connectivity Decisions: An Enhanced Online Portal for High-Resolution Barrier Data and Species-Specific Benefit AnalysesPeter Mcintyre (PI)
Michael Ferris (co-PI)
Jeffrey Dischler
Steven Wangen
Great Lakes Fishery TrustCenter for Limnology2015
Institute for Foundations of Data ScienceStephen Wright (PI)
Robert Nowak (co-PI)
National Science FoundationData Science Hub2017
Integration of Modern Convex and Integer Optimization Approaches in Stochastic Mixed-Integer ProgrammingJim Luedtke (PI)
Stephen Wright (co-PI)
Jeff Linderoth (co-PI)
National Science FoundationData Science Hub2016
Interactions and Community Dynamics in Multi-species Communities of Soil BacteriaKalin Vetsigian (PI)
Sailendharan Sudakaran
National Science Foundation2015
Investigating energy, efficiency, information processing and control architectures of microbial community interaction networksJo Handelsman (PI)
Ophelia Venturelli (Co-PI)
University of Southern California (MURI)2019
Investigating the Epigenetic Nature of Chromatin StatesPeter Lewis (PI)Pew Charitable TrustDepartment of Biomolecular Chemistry2016
Linking Mitochondrial Variation and Lifespan Amongst Five Species of  RodentiaJohn Denu (PI)DHHS
National Institutes of Health
Multi-Omics Hub2016
Mathematical Foundations of Secure Computing CloudsRobert Nowak (PI)
Stephen Wright (Co-PI)
Jordan Ellenberg (co-PI)
Department of Defense - Air ForceData Science Hub2013
Mechanisms and Environmental Determinants of Rhinovirus Illness SeverityAnn Palmenberg (PI)
John Yin (co-PI)
Huicheng Shi
DHHS
National Institutes of Health
Department of Pediatrics2013
Mixed-Integer Quadratic Optimization: Algorithms and ComplexityAlberto Del Pia (PI)Department of Defense - Navy2019
Network-Enabled Optimization System (NEOS)Michael Ferris (PI)
Michelle Craft
Morgridge Institute for Research2010
Oncohistones: Role of Histone H3 Mutations in the Oncogenesis of Pediatric CancerPeter Lewis (PI)
Aayushi Jain
Siddhant Jain
National Institutes of HealthDepartment of Biomedical Engineering2015
Organoid Microarrays for pan-Hindbrain and Spinal Cord ScreeningRandolph Ashton (PI)
Nisha Iyer
Gavin Knight
Burroughs Wellcome2014
Performance Evaluation of Light-Weight Triaxial BiocompositesShaoqin (Sarah) Gong (PI)Forest Service
US Department of Agriculture
Department of Biomedical Engineering2013
Peripheral Nerve-On-A-Chip for Predictive Preclinical Pharmaceutical TestingAxoSimDepartment of Biomedical Engineering2018
Physical and Chemical Origins of LifeJohn Yin (PI)Wisconsin Alumni Research Foundation2015
Role of Higher-Order Interactions for Stability of Microbial CommunitiesKalin Vetsigian (PI)
Seyfullah Kotil
Ye Xu
Simons Foundation2015
Role of Histone Modifying Enzymes in TumorigenesisRupa Sridharan (PI)Kimmel FoundationDepartment of Cell and Regenerative Biology2015
Shaw Scientist AwardPeter Lewis (PI)Greater Milwaukee FoundationDepartment of Biomolecular Chemistry2015
Shaw Scientist AwardRupa Sridharan (PI)Greater Milwaukee Foundation2013
SI2-SSI: Pegasus: Automating Complete and Data Intensive ScienceMiron Livny (PI)University of Southern California (NSF)Data Science Hub2017
Single Cell Profiling To Define Biomarkers Of Photoreceptor Dysfunction After Gene Editing Within IPSC-Derived OrganoidsKrishanu Saha (PI)
Sushmita Roy (co-PI)
David Gamm (co-PI)
Melissa Skala (co-PI)
DHHS
National Institutes of Health
Department of Biomedical Engineering
Department of Cell and Regenerative Biology
Department of Pediatrics
2018
Targeted Therapy of Neuroendocrine Cancers via the Notch Signaling PathwayShaoqin (Sarah) Gong (PI)DHHS
National Institutes of Health
Department of Biomedical Engineering2013
Targeted Treatment for Pulmonary Hypertension Associated with Congenital Diaphragmatic HerniaDavid McCulley (PI)
Shaoqin (Sarah) Gong (co-PI)
Institute for Clinical and Translational Research at UW-MadisonDepartment of Pediatrics2017
Targeting Triple Negative Breast Cancer Using Nanoparticles Loaded with the Anti-Cancer Drug AminoflavoneShaoqin (Sarah) Gong (PI)
Wei Xu (PI)
DHHS
National Institutes of Health
Department of Oncology2016
The Multifaceted Mathematics Center for Complex Energy SystemsMichael Ferris (PI)
Jeff Linderoth (co-PI)
Jim Luedtke (co-PI)
Stephen Wright (co-PI)
Bernard Lesiutre (co-PI)
Chris DeMarco (co-PI)
Victor Zavala (co-PI)
Clément Royer
Carla Michini
Ching-pei Lee
Argonne National Laboratory (Department of Energy)Data Science Hub2012
Tiny EarthJo Handelsman (PI)
Josh Pultorak
American Society for Microbiology
University of Connecticut
Wisconsin Institute for Discovery
2012
Tiny Earth Advanced: A Research Course SeriesJo Handelsman (PI)Howard Hughes Medical Institute2019
Tiny Earth Database ProjectJo Handelsman (PI)Alfred P. Sloan FoundationIlluminating Discovery Hub2017
Tiny Earth Wisconsin Partner Instructor Training and Supporting Community EngagementJo Handelsman (PI)Silicon Valley Community Foundation2018
Uncovering the Epigenetic Codes for Genome Integrity and Environmental InteractionXuehua Zhong (PI)
Shuiming Qian
DHHS
National Institutes of Health
Multi-Omics Hub2017
Using an Evolutionary Framework to Study Robustness and Predictive Power of Data-Driven Molecular Regulatory NetworksSushmita Roy (PI)
Sara Knaack
Junha Shin
James S McDonnell FoundationData Science Hub2016
vizHOME: A Context-Based Health Information Needs Assessment StrategyKevin Ponto (PI)
Pascale Carayon
Nicole Werner
Susan Zahner
Ross Tredinnick
Agency for Healthcare Research and Quality
DHHS
2013