New Technology for Controlling Neural Tissue Manufacturing

A paper published in eLife this week by an interdisciplinary team at WID describes new methods for reproducibly manufacturing brain and spinal cord organoids with strict control over morphogenic and developmental processes.

Scientists Discovered How PCK1 Gene Is Involved In Diabetes and Metastasis in Some Types of Cancer

An international team of researchers including WID scientists has discovered new mechanisms to regulate the activity of a gene essential in metabolism, with implications for pathologies related to alterations in glucose levels in the body, such as diabetes or metastasis in some types of cancer.

Weaning Crops from Nitrogen Fertilizers: Examining Evolution’s Innovations

WID researcher Sushmita Roy and collaborators at UW­–Madison and the University of Florida will use a $7 million grant from the U.S. Department of Energy to study how some plants partner with bacteria to create usable nitrogen and to transfer this ability to the bioenergy crop poplar.

Connecting the Dots: a New Method to Understand Cell Type Transitions

Wisconsin Institute for Discovery (WID) researchers Rupa Sridharan and Sushmita Roy are combining their expertise in regenerative biology and computational biology to better understand how cells transition from one type to another through gene regulation.

Inference and Evolutionary Analysis of Genome-Scale Regulatory Networks in Large Phylogenies

In a paper in Cell Systems, Sushmita Roy and colleagues develop a probabilistic graphical model-based method, multi-species regulatory network learning that uses a phylogenetic framework to infer regulatory networks in multiple species simultaneously.

Catching up: UW-Madison, Sheriff’s Office team up to study 3-D crime-scene tools

Kevin Ponto, a Principal Investigator in the Living Environments Lab is partnering with the Dane County Sheriff’s Office on a two-year, federally funded study to measure the effectiveness of virtual reality tools and 3-D-capture technology on crime scene investigations.